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The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

Title
The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
Authors
Zhang, YingPark, JiyoungHan, Seong-JeongPark, IhaThang Nguyen HuuKim, Jong-SukWoo, Hyun AeLee, Seung-Rock
Ewha Authors
우현애
SCOPUS Author ID
우현애scopus
Issue Date
2021
Journal Title
FREE RADICAL BIOLOGY AND MEDICINE
ISSN
0891-5849JCR Link

1873-4596JCR Link
Citation
FREE RADICAL BIOLOGY AND MEDICINE vol. 162, pp. 141 - 148
Keywords
AlcoholHepatic steatosisAlcoholic fatty liver diseasePTENReactive oxygen speciesPeroxiredoxin III
Publisher
ELSEVIER SCIENCE INC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of ROS and the underlying cellular mechanisms are unknown. Here, we investigate roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in the alcoholic fatty liver. Alcohol-induced mitochondrial oxidative stress was found to contribute to reversible oxidation of PTEN, which results in Akt and MAPK hyperactivation with elevated levels of the lipogenesis regulators SREBP1c and PPAR gamma. Moreover, mitochondrial peroxiredoxin III was found to have antagonistic effects on lipogenesis via the redox regulation of PTEN by removing ROS, upon alcohol exposure. This study demonstrated that redox regulation of PTEN and peroxiredoxin III play crucial roles in the development of AFLD.
DOI
10.1016/j.freeradbiomed.2020.11.022
Appears in Collections:
약학대학 > 약학과 > Journal papers
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