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High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice

Title
High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice
Authors
Park, HyewonLim, SangchulLee, SeunghoonMun, DasomKang, JiYoungKim, HyoeunPark, HyelimKim, ChangsooPark, SunhoLim, Yeong-MinJoung, Boyoung
Ewha Authors
박혜원
SCOPUS Author ID
박혜원scopus
Issue Date
2021
Journal Title
KOREAN CIRCULATION JOURNAL
ISSN
1738-5520JCR Link

1738-5555JCR Link
Citation
KOREAN CIRCULATION JOURNAL vol. 51, no. 2, pp. 157 - 170
Keywords
Air pollutionArrhythmiaInflammationFibrosis
Publisher
KOREAN SOC CARDIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Background and Objectives: Ambient particulate matter (PM) in real urban air pollution (RUA) is an environmental health risk factor associated with increased cardiac events. This study investigated the threshold level to induce arrhythmia, as well as arrhythmogenic mechanism of RUA that mainly consisted of PM <2.5 mu m in aerodynamic diameter close to ultrafine particles. Methods: RUA was artificially produced by a lately developed pyrolysis based RUA generator. C57BL/6 mice were divided into 4 groups: a control group (control, n=12) and three groups with exposure to RUA with the concentration of 200 mu g/m(3) (n=12), 400 mu g/m(3) (n=12), and 800 mu g/m(3) (n=12). Mice were exposed to RUA at each concentration for 8 hr/day and 5 day/week to mimic ordinary human activity during 3 weeks. Results: The QRS and QTc intervals, as well as intracellular Ca2+ duration, apicobasal action potential duration (APD) gradient, fibrosis, and inflammation of left ventricle of mouse hearts were increased dose-dependently with the increase of RUA concentration, and significantly increased at RUA concentration of 400 mu g/m(3) compared to control (all p<0.001). In mice exposed to RUA concentration of 800 mu g/m(3), spontaneous ventricular arrhythmia was observed in 42%, with significant increase of inflammatory markers, phosphorylated Ca2+/calmodulin-dependent protein kinase II (CaMKII), and phospholamban (PLB) compared to control. Conclusions: RUA could induce electrophysiological changes such as APD and QT prolongation, fibrosis, and inflammation dose-dependently, with significant increase of ventricular arrhythmia at the concentration of 400 mu g/m(3). RUA concentration of 800 mu g/m(3) increased phosphorylation of CaMKII and PLB.
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DOI
10.4070/kcj.2020.0255
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연구기관 > 의과학연구소 > Journal papers
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