Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장윤경 | - |
dc.date.accessioned | 2021-01-28T16:30:09Z | - |
dc.date.available | 2021-01-28T16:30:09Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | OAK-28725 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/256251 | - |
dc.description.abstract | Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease. However, the relationship between insulin resistance and the prognosis of acute ischemic stroke in non-diabetic patients is unclear. We hypothesized that insulin resistance might affect short-term functional recovery after acute ischemic stroke in non-diabetic patients. Between May 2014 and December 2016, 1377 consecutive patients with acute ischemic stroke were enrolled from a prospectively maintained stroke registry. After excluding patients with transient ischemic attacks (TIA), pre-stroke disabilities, diabetes mellitus, and patients with incomplete evaluations, 517 patients were included in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) score was used to evaluate the degree of insulin resistance. The patients with the highest quartile of log HOMA-IR index scores were younger and had higher fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein, and HbA1c levels. Multivariable logistic regression analysis revealed that log HOMA-IR scores were independently associated with poor prognosis after adjusting for age and sex and p < 0.1 in univariable analysis. Insulin resistance was associated with the poor functional outcome of non-diabetic stroke patients. This evidence supports treating insulin resistance in acute ischemic stroke patients with blood glucose levels within the normal range. © 2021, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.title | Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 11 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Scientific Reports | - |
dc.identifier.doi | 10.1038/s41598-020-80315-z | - |
dc.identifier.wosid | WOS:000621768900031 | - |
dc.identifier.scopusid | 2-s2.0-85099251182 | - |
dc.author.google | Chang Y. | - |
dc.author.google | Kim C.K. | - |
dc.author.google | Kim M.-K. | - |
dc.author.google | Seo W.‐K. | - |
dc.author.google | Oh K. | - |
dc.contributor.scopusid | 장윤경(56525550900) | - |
dc.date.modifydate | 20230208103146 | - |