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Recent advances in biomedical applications of organic fluorescence materials with reduced singlet–triplet energy gaps

Title
Recent advances in biomedical applications of organic fluorescence materials with reduced singlet–triplet energy gaps
Authors
Nguyen V.-N.Kumar A.Lee M.H.Yoon J.
Ewha Authors
윤주영Nguyen Van Nghia
SCOPUS Author ID
윤주영scopus; Nguyen Van Nghiascopus
Issue Date
2020
Journal Title
Coordination Chemistry Reviews
ISSN
0010-8545JCR Link
Citation
Coordination Chemistry Reviews vol. 425
Keywords
Fluorescence probesPhotodynamic therapyPhotosensitizerThermally activated delayed fluorescenceTime-resolved fluorescence imaging
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Purely organic, thermally activated delayed fluorescence (TADF) materials have recently emerged as novel and attractive organic luminescent materials for use in many research fields. Motivated by the unique features of TADF fluorophores, most notably their long-lived delayed fluorescence and high triplet formation, many organic TADF fluorophores have been developed for biomedical applications. In this review, we briefly summarize recent progress in the development of intelligent TADF probes, ranging from single molecules to delicate nanomaterials, for time-resolved fluorescence imaging and biosensing in biology and medicine. Moreover, recent strategies for designing novel photosensitizers (PSs) based on donor–acceptor systems with reduced singlet–triplet energy gaps (ΔEST) for photodynamic therapy of cancer are also introduced. Finally, the main challenges of and prospects for organic molecules with reduced ΔEST for biomedical applications are discussed. © 2020 Elsevier B.V.
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DOI
10.1016/j.ccr.2020.213545
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자연과학대학 > 화학·나노과학전공 > Journal papers
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