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Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

Title
Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells
Authors
Lee, JihyeGamage, Chathurika D. B.Kim, Geum JinHillman, Prima F.Lee, ChaeyoungLee, Eun YoungChoi, HyukjaeKim, HangunNam, Sang-JipFenical, William
Ewha Authors
남상집
SCOPUS Author ID
남상집scopusscopus
Issue Date
2020
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link

1520-6025JCR Link
Citation
JOURNAL OF NATURAL PRODUCTS vol. 83, no. 10, pp. 3166 - 3172
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey's and advanced Marfey's methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial-mesenchymal transition.
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DOI
10.1021/acs.jnatprod.0c00815
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자연과학대학 > 화학·나노과학전공 > Journal papers
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