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Enhanced repair processes and iron uptake by ischemic preconditioning in the brain during the recovery phase after ischemic stroke

Title
Enhanced repair processes and iron uptake by ischemic preconditioning in the brain during the recovery phase after ischemic stroke
Authors
Kim H.W.Shin J.A.Kim H.-J.Ahn J.-H.Park E.-M.
Ewha Authors
박은미안정혁김현정신진아
SCOPUS Author ID
박은미scopus; 안정혁scopus; 김현정scopus; 신진아scopus
Issue Date
2021
Journal Title
Brain Research
ISSN
0006-8993JCR Link
Citation
Brain Research vol. 1750
Keywords
Brain repairIron metabolismIschemic preconditioningMyelinationNeurite outgrowthPost-stroke recovery
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Ischemic preconditioning (IP) reduces brain damage after subsequent ischemic strokes by activating endogenous protective mechanisms in rodents. Transient ischemic attack (TIA) induces tolerance in the human brain after ischemic strokes; defining mechanisms of IP effects may provide therapeutic targets to improve recovery of patients with ischemic strokes. Iron transported across the blood–brain barrier (BBB) is required for brain functions, including myelination, and its levels should be finely regulated to avoid harmful effects. This study aimed to determine whether IP enhances repair processes by modulating iron metabolism during the post-stroke chronic phase. Male mice were divided into sham and IP groups, and IP was induced 24 h before a transient focal ischemic stroke. Sensorimotor recovery was observed over 8 weeks after the stroke, and brain volumes and levels of proteins related to repair processes and iron metabolism in the ischemic brains were examined 8 weeks after the stroke. There was significantly less ischemic brain atrophy in the IP group than in the sham group, with no differences in sensorimotor recovery between the groups. Levels of tight junction proteins of BBB, neurites outgrowth markers, and myelin sheath proteins and markers for mature oligodendrocytes were significantly increased in the IP group. Iron import proteins, transferrin receptor 1 and DMT1, were also increased in the IP group. These results indicate that IP increases brain repair processes and iron uptake during the chronic phase after an ischemic stroke, and provide new insights to understand the molecular mechanisms of TIA effects on post-stroke recovery. © 2020 Elsevier B.V.
DOI
10.1016/j.brainres.2020.147172
Appears in Collections:
의과대학 > 의학과 > Journal papers
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