Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤영대 | - |
dc.contributor.author | 박인영 | - |
dc.date.accessioned | 2021-01-14T16:30:15Z | - |
dc.date.available | 2021-01-14T16:30:15Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.other | OAK-28575 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255958 | - |
dc.description.abstract | Lck-interacting transmembrane adaptor 1 (LIME) has been previously identified as a raft-associated transmembrane protein expressed predominantly in T and B lymphocytes. Although LIME is shown to transduce the immunoreceptor signaling and immunological synapse formation via its tyrosine phosphorylation by Lck, a Src-family kinase, the in vivo function of LIME has remained elusive in the previous studies. Here we report that LIME is preferentially expressed in effector T cells and mediates chemokine-mediated T cell migration. Interestingly, in LIME-/- mice, while T cell receptor stimulation-dependent proliferation, differentiation to effector T cells, cytotoxic T lymphocyte (CTL) function and regulatory T lymphocyte (Treg) function were normal, only T cell-mediated inflammatory response was significantly defective. The reduced inflammation was accompanied by the impaired infiltration of leukocytes and T cells to the inflammatory sites of LIME-/- mice. More specifically, the absence of LIME in effector T cells resulted in the reduced migration and defective morphological polarization in response to inflammatory chemokines such as CCL5 and CXCL10. Consistently, LIME-/- effector T cells were found to be defective in chemokine-mediated activation of Rac1 and Rap1, and dysregulated phosphorylation of Pyk2 and Cas. Taken together, the present findings show that LIME is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MOLECULAR & | - |
dc.publisher | CELLULAR BIOLOGY | - |
dc.subject | chemokine | - |
dc.subject | effector T cells | - |
dc.subject | Lck-interacting transmembrane adaptor 1 | - |
dc.subject | migration | - |
dc.title | The Transmembrane Adaptor Protein LIME Is Essential for Chemokine-Mediated Migration of Effector T Cells to Inflammatiory Sites | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 43 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 921 | - |
dc.relation.lastpage | 934 | - |
dc.relation.journaltitle | MOLECULES AND CELLS | - |
dc.identifier.doi | 10.14348/molcells.2020.0124 | - |
dc.identifier.wosid | WOS:000595593300003 | - |
dc.author.google | Park, Inyoung | - |
dc.author.google | Son, Myongsun | - |
dc.author.google | Ahn, Eunseon | - |
dc.author.google | Kim, Young-Woong | - |
dc.author.google | Kong, Young-Yun | - |
dc.author.google | Yun, Yungdae | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.contributor.scopusid | 박인영(7403243197;56302476200) | - |
dc.date.modifydate | 20230118102324 | - |