Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조정민 | - |
dc.date.accessioned | 2021-01-14T16:30:13Z | - |
dc.date.available | 2021-01-14T16:30:13Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.other | OAK-28596 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255938 | - |
dc.description.abstract | Cisplatin is an effective chemotherapeutic agent, but its clinical use is frequently limited by its nephrotoxicity. The pathogenesis of cisplatin-induced acute kidney injury (AKI) remains incompletely understood, but oxidative stress, tubular cell death, and inflammation are considered important contributors to cisplatin-induced renal injury. Kahweol is a natural diterpene extracted from coffee beans and has been shown to possess anti-oxidative and anti-inflammatory properties. However, its role in cisplatin-induced nephrotoxicity remains undetermined. Therefore, we investigated whether kahweol exerts a protective effect against cisplatin-induced renal injury. Additionally, its mechanisms were also examined. Administration of kahweol attenuated renal dysfunction and histopathological damage together with inhibition of oxidative stress in cisplatin-injected mice. Increased expression of nicotinamide adenine dinucleotide phosphate oxidase 4 and decreased expression of manganese superoxide dismutase and catalase after cisplatin treatment were significantly reversed by kahweol. Moreover, kahweol inhibited cisplatin-induced apoptosis and necroptosis in the kidneys. Finally, kahweol reduced inflammatory cytokine production and immune cell accumulation together with suppression of nuclear factor kappa-B pathway and downregulation of vascular adhesion molecules. Together, these results suggest that kahweol ameliorates cisplatin-induced renal injury via its pleiotropic effects and might be a potential preventive option against cisplatin-induced nephrotoxicity. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.subject | cisplatin | - |
dc.subject | coffee | - |
dc.subject | kahweol | - |
dc.subject | acute kidney injury | - |
dc.subject | oxidative stress | - |
dc.subject | apoptosis | - |
dc.subject | necroptosis | - |
dc.subject | inflammation | - |
dc.title | Kahweol Ameliorates Cisplatin-Induced Acute Kidney Injury through Pleiotropic Effects in Mice | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 8 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | BIOMEDICINES | - |
dc.identifier.doi | 10.3390/biomedicines8120572 | - |
dc.identifier.wosid | WOS:000601768800001 | - |
dc.author.google | Kim, Jung-Yeon | - |
dc.author.google | Jo, Jungmin | - |
dc.author.google | Leem, Jaechan | - |
dc.author.google | Park, Kwan-Kyu | - |
dc.date.modifydate | 20220301081001 | - |