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dc.contributor.author서은경-
dc.contributor.author임경민-
dc.contributor.author남상집-
dc.contributor.author김민정-
dc.date.accessioned2021-01-14T16:30:12Z-
dc.date.available2021-01-14T16:30:12Z-
dc.date.issued2020-
dc.identifier.issn1420-3049-
dc.identifier.otherOAK-28602-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/255933-
dc.description.abstractLycii Fructus is a traditional medicine used to prevent liver and kidney diseases, which commonly derives from Lycium chinense and Lycium barbarum. Here, the extracts and ethyl acetate-soluble fractions of L. chinense fruits exhibited better hepatoprotective effects than those of L. barbarum, which was likely due to differences in their composition. Therefore, GC-MS and HPLC analyses were conducted to characterize the metabolite differences between L. chinense and L. barbarum. Based on amino acid (AA) and phenolic acid (PA) profiling, 24 AAs and 9 PAs were identified in the two species. Moreover, each species exhibited unique and readily distinguishable AA and PA star graphic patterns. HPLC analysis elucidated composition differences between the ethyl acetate-soluble layers of the two compounds. Further, NMR analysis identified their chemical structures as 4-(2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl)butanoic acid and p-coumaric acid. The higher content of 4-(2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl)butanoic acid was detected in L. chinense, whereas the content of p-coumaric acid was higher in L. barbarum. Therefore, the differences in the relative contents of these two secondary metabolites in the ethyl acetate-soluble layer of Lycii Fructus could be a good marker to discriminate between L. chinense and L. barbarum.-
dc.languageEnglish-
dc.publisherNLM (Medline)-
dc.subjectgas chromatography-mass spectrometry-
dc.subjectLycium barbarum-
dc.subjectLycium chinense-
dc.subjectstar pattern recognition analysis-
dc.titleDiscrimination of Lycium chinense and L. barbarum Based on Metabolite Analysis and Hepatoprotective Activity-
dc.typeArticle-
dc.relation.issue24-
dc.relation.volume25-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleMolecules (Basel, Switzerland)-
dc.identifier.doi10.3390/molecules25245835-
dc.identifier.wosidWOS:000603343200001-
dc.identifier.scopusid2-s2.0-85098532519-
dc.author.googleRyu M.-J.-
dc.author.googleKim M.-
dc.author.googleJi M.-
dc.author.googleLee C.-
dc.author.googleYang I.-
dc.author.googleHong S.-B.-
dc.author.googleChin J.-
dc.author.googleSeo E.K.-
dc.author.googlePaik M.-J.-
dc.author.googleLim K.-M.-
dc.author.googleNam S.-J.-
dc.contributor.scopusid서은경(7005953758)-
dc.contributor.scopusid임경민(8916551700)-
dc.contributor.scopusid남상집(57208839798;36455982300)-
dc.contributor.scopusid김민정(56999341200)-
dc.date.modifydate20210915112221-
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약학대학 > 약학과 > Journal papers
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