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Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis
- Title
- Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis
- Authors
- Jung, Minyoung; Kim, Insung; Lee, Ji Young; Kim, Hyun Mi; Kwon, Mijeong; Kim, Minjeong; Lim, Kyung-Min; Kim, Peter S.; Ahn, Kangmo; Kim, Jihyun
- Ewha Authors
- 임경민; 김민정
- SCOPUS Author ID
- 임경민; 김민정
- Issue Date
- 2020
- Journal Title
- ALLERGOLOGY INTERNATIONAL
- ISSN
- 1323-8930
1440-1592
- Citation
- ALLERGOLOGY INTERNATIONAL vol. 69, no. 3, pp. 429 - 436
- Keywords
- Air movements; Atopic dermatitis; Environmental impact; Filaggrin; Wind
- Publisher
- JAPANESE SOCIETY ALLERGOLOGY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD). Methods: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. We also measured filaggrin and FDPs from the volar surface of the forearm. Results: In AD patients, skin temperature on the forearm decreased after exposure to the conventional and wind-free modes (P < 0.001 and P = 0.026), and TEWL on the cheek and the forearm decreased in the wind-free mode (P = 0.037 and 0.002). Skin pH on the cheek increased only after exposure to the conventional mode in AD group (P = 0.002). However, no changes in TEWL and skin pH were found after exposure to either the conventional or the wind-free mode in the control group. In AD children, the levels of pyrrolidone carboxylic acid (PCA) and cis-urocanic acid (UCA) were reduced only after exposure to the conventional mode (all P = 0.033). The percent changes of PCA and cis-UCA were higher in the AD group than those in the control group after exposure to conventional mode (P = 0.029 and 0.046). Conclusions: Skin barrier function in children with AD may be altered by the exposure to cold airflow from a conventional air conditioner. Copyright (C) 2019, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
- DOI
- 10.1016/j.alit.2019.11.004
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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