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Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis

Title
Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis
Authors
Jung, MinyoungKim, InsungLee, Ji YoungKim, Hyun MiKwon, MijeongKim, MinjeongLim, Kyung-MinKim, Peter S.Ahn, KangmoKim, Jihyun
Ewha Authors
임경민김민정
SCOPUS Author ID
임경민scopus; 김민정scopusscopus
Issue Date
2020
Journal Title
ALLERGOLOGY INTERNATIONAL
ISSN
1323-8930JCR Link

1440-1592JCR Link
Citation
ALLERGOLOGY INTERNATIONAL vol. 69, no. 3, pp. 429 - 436
Keywords
Air movementsAtopic dermatitisEnvironmental impactFilaggrinWind
Publisher
JAPANESE SOCIETY ALLERGOLOGY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD). Methods: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. We also measured filaggrin and FDPs from the volar surface of the forearm. Results: In AD patients, skin temperature on the forearm decreased after exposure to the conventional and wind-free modes (P < 0.001 and P = 0.026), and TEWL on the cheek and the forearm decreased in the wind-free mode (P = 0.037 and 0.002). Skin pH on the cheek increased only after exposure to the conventional mode in AD group (P = 0.002). However, no changes in TEWL and skin pH were found after exposure to either the conventional or the wind-free mode in the control group. In AD children, the levels of pyrrolidone carboxylic acid (PCA) and cis-urocanic acid (UCA) were reduced only after exposure to the conventional mode (all P = 0.033). The percent changes of PCA and cis-UCA were higher in the AD group than those in the control group after exposure to conventional mode (P = 0.029 and 0.046). Conclusions: Skin barrier function in children with AD may be altered by the exposure to cold airflow from a conventional air conditioner. Copyright (C) 2019, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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DOI
10.1016/j.alit.2019.11.004
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약학대학 > 약학과 > Journal papers
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