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Glycosaminoglycan-Induced Emissive J-Aggregate Formation in a meso-Ester BODIPY Dye

Title
Glycosaminoglycan-Induced Emissive J-Aggregate Formation in a meso-Ester BODIPY Dye
Authors
Kim, DamiLee, UisungBouffard, JeanKim, Youngmi
Ewha Authors
Jean Bouffard
SCOPUS Author ID
Jean Bouffardscopus
Issue Date
2020
Journal Title
ADVANCED OPTICAL MATERIALS
ISSN
2195-1071JCR Link
Citation
ADVANCED OPTICAL MATERIALS vol. 8, no. 14
Keywords
aggregation-induced emission (AIE)BODIPYfluorescent probesheparinJ-aggregates
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
The analyte-directed formation of emissive J-aggregates of a meso-ester BODIPY dye is explored in the design of fluorescence "light-up" probes. The heparin-specific pyridinium-functionalized meso-ester BODIPY dye C10-Py+ self-assembles in aqueous buffer into spherical aggregated nanostructures with spectroscopic features indistinguishable from the monomeric dye (signal off). In the presence of heparin, the aggregated assemblies rearrange and associate with heparin through charge-pairing interactions, triggering the spontaneous formation of emissive J-type aggregates (signal on). The heparin-induced J-aggregate formation of C10-Py+ provides an excellent "turn-on" signal with large spectral shifts. The response is highly selective for heparin over other closely related glycosaminoglycan (GAG) analogues, sensitive, fast, and operationally simple. Assays for heparin in human serum, and for the adulterant OSCS in heparin are demonstrated, confirming the reliability and robustness of the J-aggregation approach using meso-ester BODIPY dyes in the design of aggregation-induced emission (AIE)-based fluorogenic probes.
DOI
10.1002/adom.201902161
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자연과학대학 > 화학·나노과학전공 > Journal papers
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