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Obesity May Connect Insulin Resistance to Decreased Neuronal Viability in Human Diabetic Brain

Title
Obesity May Connect Insulin Resistance to Decreased Neuronal Viability in Human Diabetic Brain
Authors
Lee, SujiJoo, Yoon JiKim, Rye YoungHwang, JaeukLim, Soo MeeYoon, SujungKim, Jungyoon
Ewha Authors
임수미윤수정김정윤
SCOPUS Author ID
임수미scopus; 윤수정scopus; 김정윤scopus
Issue Date
2020
Journal Title
OBESITY
ISSN
1930-7381JCR Link

1930-739XJCR Link
Citation
OBESITY vol. 28, no. 9, pp. 1626 - 1630
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objective This study aimed to investigate the relationship between insulin resistance and markers of neuronal viability and energy metabolism, as well as the additive effects of overweight or obesity, in individuals with type 2 diabetes mellitus (T2DM). Methods Using(1)H-magnetic resonance spectroscopy, prefrontalN-acetyl aspartate (NAA) and creatine levels, markers for neuronal viability and energy metabolism, respectively, were measured in 50 adults with overweight or obesity and T2DM (T2DM-O; aged 49.0 +/- 7.4 years; 50% female), 50 adults with normal weight and T2DM (T2DM-N), and 50 healthy adults with normal weight (healthy-control [HC] group) matched for age and sex. The homeostatic model assessment for insulin resistance levels were calculated to assess insulin resistance. Results Prefrontal NAA levels were lower in the T2DM-O group relative to the HC group (t = -2.51,P = 0.013). Higher insulin resistance was associated with lower prefrontal NAA levels in the T2DM-O group (t = -2.21,P = 0.032) but not in the T2DM-N group (t = -0.72,P = 0.48). Prefrontal creatine levels did not differ across the three groups. Conclusions Overweight and obesity might contribute to T2DM-related neuronal viability deficits and could be the key links that connect insulin resistance to the decreased neuronal viability in the human diabetic brain.
DOI
10.1002/oby.22869
Appears in Collections:
의과대학 > 의학과 > Journal papers
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