View : 126 Download: 0

The role of sphingolipids in endoplasmic reticulum stress

Title
The role of sphingolipids in endoplasmic reticulum stress
Authors
Park, Woo-JaePark, Joo-Won
Ewha Authors
박주원
SCOPUS Author ID
박주원scopus
Issue Date
2020
Journal Title
FEBS LETTERS
ISSN
0014-5793JCR Link

1873-3468JCR Link
Citation
FEBS LETTERS vol. 594, no. 22, pp. 3632 - 3651
Keywords
acyl chain lengthceramidediseaseendoplasmic reticulum stresssphingolipid
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
The endoplasmic reticulum (ER) is an important intracellular compartment in eukaryotic cells and has diverse functions, including protein synthesis, protein folding, lipid metabolism and calcium homeostasis. ER functions are disrupted by various intracellular and extracellular stimuli that cause ER stress, including the inhibition of glycosylation, disulphide bond reduction, ER calcium store depletion, impaired protein transport to the Golgi, excessive ER protein synthesis, impairment of ER-associated protein degradation and mutated ER protein expression. Distinct ER stress signalling pathways, which are known as the unfolded protein response, are deployed to maintain ER homeostasis, and a failure to reverse ER stress triggers cell death. Sphingolipids are lipids that are structurally characterized by long-chain bases, including sphingosine or dihydrosphingosine (also known as sphinganine). Sphingolipids are bioactive molecules long known to regulate various cellular processes, including cell proliferation, migration, apoptosis and cell-cell interaction. Recent studies have uncovered that specific sphingolipids are involved in ER stress. This review summarizes the roles of sphingolipids in ER stress and human diseases in the context of pathogenic events.
Show the fulltext
DOI
10.1002/1873-3468.13863
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE