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Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer

Title
Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer
Authors
Jang, BoheeKim, AyoungHwang, JisunSong, Hyun-KukKim, YunjeonOh, Eok-Soo
Ewha Authors
오억수황지선장보희
SCOPUS Author ID
오억수scopus; 황지선scopus; 장보희scopus
Issue Date
2020
Journal Title
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
ISSN
0022-1554JCR Link

1551-5044JCR Link
Citation
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY vol. 68, no. 12, pp. 863 - 870
Keywords
cancerECM remodelingextracellular matrixglycosaminoglycanmatrix metalloproteasesyndecan
Publisher
SAGE PUBLICATIONS LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly common in the development of cancer. The ECM has been recognized as a key driver of cancer development and progression, and ECM remodeling occurs at all stages of cancer progression. Thus, cancer cells need to change the ECM to support relevant cell surface adhesion receptor-mediated cell functions. In this context, it is interesting to examine how cancer cells regulate ECM remodeling, which is critical to tumor malignancy and metastatic progression. Here, we review how the cell surface adhesion receptor, syndecan, regulates ECM remodeling as cancer progresses, and explore how this can help us better understand ECM remodeling under these pathological conditions
DOI
10.1369/0022155420930112
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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