View : 533 Download: 0
Sex differences in the blood pressure level associated with increased risks of cardiovascular events: a Korean nationwide population-based cohort study
- Title
- Sex differences in the blood pressure level associated with increased risks of cardiovascular events: a Korean nationwide population-based cohort study
- Authors
- Kee, Youn Kyung; Kim, Min-ho; Oh, Jongmin; Oh, Hyung Jung; Ryu, Dong-Ryeol
- Ewha Authors
- 류동열; 오형중
- SCOPUS Author ID
- 류동열; 오형중
- Issue Date
- 2020
- Journal Title
- JOURNAL OF CLINICAL HYPERTENSION
- ISSN
- 1524-6175
1751-7176
- Citation
- JOURNAL OF CLINICAL HYPERTENSION vol. 22, no. 9, pp. 1638 - 1646
- Keywords
- antihypertensive-treated patients; blood pressure; hypertension; major cardiac and cerebral events; sex differences
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Hypertension is a leading risk factor for cardiovascular events and death. Despite differences in clinical implications of hypertension between men and women, guidelines establishing optimal blood pressure (BP) targets are still debated. The aim of this study was to investigate sex differences in the BP level associated with increased risks of major adverse cardiac and cerebral events (MACCEs) among antihypertensive-treated patients. Using data from the Korean National Health Insurance Service-National Sample Cohort, we enrolled antihypertensive-treated patients and divided them into four categories: Group 1: SBP < 120 and DBP < 80 mm Hg; Group 2: 120 <= SBP < 130 and DBP < 80 mm Hg; Group 3: 130 <= SBP < 140 or 80 <= DBP < 90 mm Hg; and Group 4: SBP >= 140 or DBP >= 90 mm Hg. We performed time-dependent cox regression analysis to investigate sex differences in the BP levels that increased the risk of MACCEs. Most of the 98 267 patients fell into Group 3 (53.2% men and 52.8% women) and Group 4 (30.5% men and 28.1% women). During 8.34 +/- 2.07 years, there were 8,813 MACCEs and 791 deaths. The incidences of MACCEs and death tended to increase as the BP increased in both sexes. Compared to Group 1, the risk of MACCEs significantly increased only in Group 4 for men, while it significantly increased in Groups 3 and 4 for women. This study shows that there are sex differences in the BP level at which the risk of MACCEs increases. Our finding suggests that sex should be significantly considered when determining the optimal BP target in patients undergoing hypertension treatment.
- DOI
- 10.1111/jch.13990
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML