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Incidence, Long-Term Visual Outcomes, and Mortality in Retinopathy of Prematurity in Korea: A Nationwide Population-Based Study

Title
Incidence, Long-Term Visual Outcomes, and Mortality in Retinopathy of Prematurity in Korea: A Nationwide Population-Based Study
Authors
Na, Kun-HooKim, Kyoung HoonKang, Tae UkHann, Hoo JaeAhn, Hyeong SikKim, Hyun Jung
Ewha Authors
한후재
SCOPUS Author ID
한후재scopus
Issue Date
2020
Journal Title
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
ISSN
0146-0404JCR Link

1552-5783JCR Link
Citation
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE vol. 61, no. 10
Keywords
retinopathy of prematurityincidencevisual prognosismortality
Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
PURPOSE. To evaluate the incidence, visual prognosis, and mortality in retinopathy of prematurity (ROP) in Korea. METHODS. We used the National Health Insurance and the Korean Disability Registry database, which covers the entire newborn population in 2006 to 2014 and includes information on all newborns diagnosed with ROP until 2016. Using these databases, we evaluated the incidence, rate of visual impairment (VI), and mortality in patients with ROP according to the birth weight categories and treatment modalities. RESULTS. The ROP incidence per 1000 newborns was 1.99, which broke down into 317.14 in the very low birth weight (VLBW) less than 1500 g population, 25.45 in the 1500 to 2499 g population, and 0.29 in the 2500 g or greater population. When assessed at age 10, the VI rate was 2.2 per 100 person-years, which was highest at 4.5 per 100 person-years in the VLBWpopulation compared with the population in other birth weight categories. Among treated cases, the proportion of VI in patients undergoing laser photocoagulation or cryotherapy was 1.6% (42/2595), which was lower than the 2.9% (2/68) of patients treated with anti-vascular endothelial growth factor injection, and 32.2% (82/255) of patients undergoing vitrectomy or scleral buckling. The mortality rate was 4.8 per 1000 person-years, which was highest in the VLBW population, but similar across treatment modalities. CONCLUSIONS. The ROP incidence in Korea was approximately 1 in 500 among all newborns, and 1 in 3 in the VLBW population. As the first nationwide population-based study of long-term visual prognosis in ROP, we report the higher VI rate in ROP than previously determined in other studies. Differences in visual outcomes and comparable mortality risks between treatment modalities require further verification.
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DOI
10.1167/iovs.61.10.14
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의과대학 > 의학과 > Journal papers
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