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Association between chronic pain and alterations in the mesolimbic dopaminergic system

Title
Association between chronic pain and alterations in the mesolimbic dopaminergic system
Authors
Yang S.Boudier-Revéret M.Choo Y.J.Chang M.C.
Ewha Authors
양서연
Issue Date
2020
Journal Title
Brain Sciences
ISSN
2076-3425JCR Link
Citation
Brain Sciences vol. 10, no. 10, pp. 1 - 14
Keywords
AddictionChronic painDepressionDopaminergic drugDopaminergic systemMesolimbic system
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Chronic pain (pain lasting for >3 months) decreases patient quality of life and even occupational abilities. It can be controlled by treatment, but often persists even after management. To properly control pain, its underlying mechanisms must be determined. This review outlines the role of the mesolimbic dopaminergic system in chronic pain. The mesolimbic system, a neural circuit, delivers dopamine from the ventral tegmental area to neural structures such as the nucleus accumbens, prefrontal cortex, anterior cingulate cortex, and amygdala. It controls executive, affective, and motivational functions. Chronic pain patients suffer from low dopamine production and delivery in this system. The volumes of structures constituting the mesolimbic system are known to be decreased in such patients. Studies on administration of dopaminergic drugs to control chronic pain, with a focus on increasing low dopamine levels in the mesolimbic system, show that it is effective in patients with Parkinson’s disease, restless legs syndrome, fibromyalgia, dry mouth syndrome, lumbar radicular pain, and chronic back pain. However, very few studies have confirmed these effects, and dopaminergic drugs are not commonly used to treat the various diseases causing chronic pain. Thus, further studies are required to determine the effectiveness of such treatment for chronic pain. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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DOI
10.3390/brainsci10100701
Appears in Collections:
의료원 > 의료원 > Journal papers
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