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Astrocytic Calcium Dynamics Along the Pain Pathway

Title
Astrocytic Calcium Dynamics Along the Pain Pathway
Authors
Cho J.Huh Y.
Ewha Authors
조제원
Issue Date
2020
Journal Title
Frontiers in Cellular Neuroscience
ISSN
1662-5102JCR Link
Citation
Frontiers in Cellular Neuroscience vol. 14
Keywords
astrocytecalciumcalcium channelschronic paininflammatory painneuropathic painpain pathway
Publisher
Frontiers Media S.A.
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Astrocytes, once thought to be passive cells merely filling the space between neurons in the nervous system, are receiving attention as active modulators of the brain and spinal cord physiology by providing nutrients, maintaining homeostasis, and modulating synaptic transmission. Accumulating evidence indicates that astrocytes are critically involved in chronic pain regulation. Injury induces astrocytes to become reactive, and recent studies suggest that reactive astrocytes can have either neuroprotective or neurodegenerative effects. While the exact mechanisms underlying the transition from resting astrocytes to reactive astrocytes remain unknown, astrocytic calcium increase, coordinated by inflammatory molecules, has been suggested to trigger this transition. In this mini review article, we will discuss the roles of astrocytic calcium, channels contributing to calcium dynamics in astrocytes, astrocyte activations along the pain pathway, and possible relationships between astrocytic calcium dynamics and chronic pain. © Copyright © 2020 Cho and Huh.
DOI
10.3389/fncel.2020.594216
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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