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Effects of Radiofrequency Electromagnetic Fields and Ionizing Radiation on Amyloid Precursor Protein Processing and Cell Death
- Title
- Effects of Radiofrequency Electromagnetic Fields and Ionizing Radiation on Amyloid Precursor Protein Processing and Cell Death
- Authors
- Yoon K.; Choi S.; Choi H.-D.; Kim N.; Jeon S.B.; Lim K.-M.; Lee H.-J.; Lee Y.-S.
- Ewha Authors
- 이윤실; 임경민
- SCOPUS Author ID
- 이윤실; 임경민
- Issue Date
- 2020
- Journal Title
- Journal of Electromagnetic Engineering and Science
- ISSN
- 2671-7255
- Citation
- Journal of Electromagnetic Engineering and Science vol. 20, no. 4, pp. 307 - 319
- Keywords
- Amyloid Protein Precursor Processing; Cell Death; Ionizing Radiation; RF-EMF
- Publisher
- Korean Institute of Electromagnetic Engineering and Science
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The growing concerns regarding the adverse biological effects of radiofrequency electromagnetic fields (RF-EMFs), which are generated by common electronic devices, on the human brain led us to investigate their impact on Alzheimer's disease (AD). We aimed to establish the effects of RF-EMF on the expression of molecular markers associated with amyloid precursor protein (APP), cell death, and clonogenic survival in HT22 and APP-overexpressing 7w-PSML cells. We compared the effects of RF-EMF at a high specific absorption rate (SAR) level with the neuronal-cell-death-inducing effects of ionizing radiation (IR). RF-EMF exposure (8 W/kg SAR) promoted the protein expression of ADAM10 (α-secretase) in the HT22 cells (p < 0.05) and downregulated the APP mRNA level in the 7w-PSML cells (p < 0.01). In contrast, IR (10 Gy) significantly reduced the APP and a disintegrin and metalloproteinase 10 (ADAM10) levels without altering their respective mRNA levels in these cells. Interestingly, IR exposure significantly upregulated BACE1 (β-secretase) at both the protein and mRNA levels, suggesting adverse effects in AD. IR induced cell death and reduced clonogenic survival in both cell lines. Although RF-EMF (high SAR level) influenced APP processing, it did not induce any deleterious change in either cell line. Thus, further studies are necessary to clarify the influence of RF-EMF on AD. © 2020. The Korean Institute of Electromagnetic Engineering and Science. All Rights Reserved.
- DOI
- 10.26866/jees.2020.20.4.307
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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