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Impact of chronic kidney disease on mortality: A nationwide cohort study

Title
Impact of chronic kidney disease on mortality: A nationwide cohort study
Authors
Kim K.M.Oh H.J.Choi H.Y.Lee H.Ryu D.-R.
Ewha Authors
류동열오형중
SCOPUS Author ID
류동열scopus; 오형중scopus
Issue Date
2019
Journal Title
Kidney Research and Clinical Practice
ISSN
2211-9132JCR Link
Citation
Kidney Research and Clinical Practice vol. 38, no. 3, pp. 382 - 390
Keywords
ChronicDiabetes mellitusHypertensionKoreaMortalityRenal insufficiency
Publisher
The Korean Society of Nephrology
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Background: Mortality is higher in patients with chronic kidney disease (CKD) than in the general population, but little information is available on CKD-related mortality that is representative of the Korean population. Our objective was to investigate mortality risk in Korean patients with CKD. Methods: We identified patients with incident CKD who had not undergone dialysis or kidney transplantation between January 1, 2003 and December 31, 2007 in Korea using the database of the Korean National Health Insurance Service-National Sample Cohort, and stratified the population into the following three groups: group 1 (n = 1,473), controls; group 2 (n = 2,212), patients with diabetes or hypertension, but without CKD; and group 3 (n = 2,212), patients with CKD. We then monitored them for all-cause mortality until December 2013. Results: A total of 1,473 patients were included in this analysis. During the follow-up period, 941 patients in group 3 died (134 deaths/1,000 person-years) compared with 550 deaths in the group 2 (34 deaths/1,000 person-years) and 459 deaths in group 1 (30 deaths/1,000 person-years). The rate ratio for mortality rate was 4.5, and the hazard ratio for mortality was 4.88 (95% confidence interval [CI], 4.36-5.47, P < 0.001) in patients in group 3 compared with age-and sex-matched controls (group 1). The rate ratio for mortality rate was 4.0, and the hazard ratio for mortality was 4.36 (95% CI, 3.92-4.85, P < 0.001) in patients in group 3 compared with patients in group 2. Conclusion: In this nationally representative sample cohort, excess mortality was observed in Korean patients with incident CKD. © 2019 by The Korean Society of Nephrology.
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DOI
10.23876/j.krcp.18.0128
Appears in Collections:
의과대학 > 의학과 > Journal papers
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