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Dexamethasone Promotes Keratinocyte Proliferation by Triggering Keratinocyte Growth Factor in Mast Cells

Title
Dexamethasone Promotes Keratinocyte Proliferation by Triggering Keratinocyte Growth Factor in Mast Cells
Authors
Cho, Kyung-AhKim, Hye JiKim, Yu-HeePark, MinhwaWoo, So-Youn
Ewha Authors
우소연
SCOPUS Author ID
우소연scopus
Issue Date
2019
Journal Title
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
ISSN
1018-2438JCR Link

1423-0097JCR Link
Citation
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY vol. 179, no. 1, pp. 53 - 61
Keywords
GlucocorticoidsMast cellsKeratinocyte growth factorKeratinocytes Skin
Publisher
KARGER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: The skin is a dynamic body organ that can be activated by both central and local hypothalamic-pituitaryadrenal axis systems. This phenomenon might be the crucial explanation why stress can cause relapse of chronic inflammatory skin diseases, such as psoriasis. Here, we determined the effects of mast cells on keratinocyte proliferation under stress hormone stimulation. Methods: We subcutaneously injected dexamethasone on the shaved back of mice and evaluated histological changes and keratinocyte growth factor (KGF) expression on dermal mast cells. Further, human mast cell line (HMC-1) and keratinocyte cell line (HaCaT) cells were treated with dexamethasone in vitro to observe the extent of proliferation and the expression of KGF. Finally, the supernatants of HMC-1 cells treated with dexamethasone were used for the culture of HaCaT cells to investigate the effect on proliferation. Results: We observed epidermal thickening in dexamethasone-injected mice, accompanied by an increase in the number of KGF-expressing dermal mast cells. Similar to mouse dermal mast cells, KGF was highly expressed in the human mast cell line HMC-1 following stimulation with dexamethasone. Further, dexamethasone-treated mast cells promoted keratinocyte proliferation in vitro. However, the effects of mast cells on keratinocytes were significantly diminished in the presence of anti-KGF-blocking antibodies. Conclusion: Taken together, our results show that a stressful environment may disturb skin barrier homeostasis through mast cell-derived KGF expression. (C) 2019 S. Karger AG, Basel
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DOI
10.1159/000494624
Appears in Collections:
의과대학 > 의학과 > Journal papers
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