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Silver-Impregnated Negative-Pressure Wound Therapy for the Treatment of Lower-Extremity Open Wounds: A Prospective Randomized Clinical Study

Title
Silver-Impregnated Negative-Pressure Wound Therapy for the Treatment of Lower-Extremity Open Wounds: A Prospective Randomized Clinical Study
Authors
Hahn, Hyung MinLee, Il JaeWoo, Kyong-jePark, Bo Young
Ewha Authors
박보영우경제
SCOPUS Author ID
박보영scopus; 우경제scopus
Issue Date
2019
Journal Title
ADVANCES IN SKIN & WOUND CARE
ISSN
1527-7941JCR Link

1538-8654JCR Link
Citation
ADVANCES IN SKIN & WOUND CARE vol. 32, no. 8, pp. 370 - 377
Keywords
bacterial loadlower extremitynegative-pressure wound therapyopen woundssilverwound dressing
Publisher
LIPPINCOTT WILLIAMS &

WILKINS
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Document Type
Article
Abstract
OBJECTIVE To investigate the antibacterial efficacy of silver-impregnated negative-pressure wound therapy (NPWT) in lower-extremity acute traumatic wounds. METHODS Open contaminated wounds caused by high-velocity trauma in the lower extremities were randomly allocated into two groups. The wounds in the control and experimental groups were treated with conventional NPWT (n = 31) and silver-impregnated NPWT (n = 35), respectively. MAIN OUTCOME MEASURES Serial bacterial cultures were obtained from the participants' wounds, polyurethane foam, and suction tubes weekly during the 4-week follow-up to identify bacteria and follow their conversions. MAIN RESULTS Bacterial colonization rates in the silver NPWT group were generally lower than those in the conventional NPWT group, and the difference increased with time. For methicillin-resistant Staphylococcus aureus colonization, wounds treated with silver-impregnated NPWT showed a significant reduction in bacterial load compared with those treated with conventional NPWT. CONCLUSIONS Silver-impregnated NPWT effectively decreases bacterial load in open contaminated wounds of the lower extremities. It can be used as a temporizing measure to manage bacterial colonization while patients and wounds are being prepared for final wound reconstruction.
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DOI
10.1097/01.ASW.0000569116.59534.a6
Appears in Collections:
의과대학 > 의학과 > Journal papers
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