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The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover

Title
The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover
Authors
van de Loo, Aurora J. A. E.Mackus, MarlouKwon, OranKrishnakumar, Illathu MadhavamenonGarssen, JohanKraneveld, Aletta D.Scholey, AndrewVerster, Joris C.
Ewha Authors
권오란
SCOPUS Author ID
권오란scopus
Issue Date
2020
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 9, no. 7
Keywords
alcoholhangoverethanolacetaldehydeacetateoxidative stressmalondialdehyde8-isoprostanecytokinesC-reactive protein
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
An increasing number of studies are focusing on the inflammatory response to alcohol as a potentially important determinant of hangover severity. In this article, data from two studies were re-evaluated to investigate the relationship between hangover severity and relevant biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol. Hangover severity was significantly and positively correlated with blood concentrations of biomarkers of the inflammatory response to alcohol, in particular, Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP). At 4 h after alcohol consumption, blood ethanol concentration (but not acetaldehyde) was significantly and positively associated with elevated levels of IL-6, suggesting a direct inflammatory effect of ethanol. In addition, biomarkers of oxidative stress, i.e., malondialdehyde and 8-isoprostrane, were significantly correlated with hangover severity, suggesting that oxidative stress also contributes to the inflammatory response. The timing of the assessments suggests initial slow elimination of ethanol in the first hours after alcohol consumption. As a consequence, more ethanol is present in the second half of the night and the next morning, which will elicit more oxidative stress and a more profound inflammatory response. Together, these processes result in more severe hangovers.
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DOI
10.3390/jcm9072081
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신산업융합대학 > 식품영양학과 > Journal papers
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