Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용현 | * |
dc.date.accessioned | 2020-08-20T16:30:23Z | - |
dc.date.available | 2020-08-20T16:30:23Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1433-7851 | * |
dc.identifier.issn | 1521-3773 | * |
dc.identifier.other | OAK-27582 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255066 | - |
dc.description.abstract | Peptide-based therapeutics have suffered from a short plasma half-life. On the other hand, antibodies suffer from poor penetration into solid tumors owing to their large size. Herein, we present a new molecular form, namely a hybrid complex between a hapten-labeled bispecific peptide and an anti-hapten antibody (HyPEP-body), that may be able to overcome the aforementioned limitation. The bispecific peptide containing a cotinine tag was synthesized by linking a peptide specific to fibronectin extra domainB (EDB) and a peptide able to bind and inhibit vascular endothelial growth factor (VEGF), yielding cot-biPEP(EDB-VEGF). Simple mixing of cot-biPEP(EDB-VEGF) and anti-cotinine antibody (Ab(cot)) yielded the hybrid complex, HyPEP(EDB-VEGF). HyPEP(EDB-VEGF) retained the characteristics of the included peptides, and showed improved pharmacokinetic behavior. Moreover, HyPEP(EDB-VEGF) showed tumor growth inhibition with excellent tumor accumulation and penetration. These findings suggest that the hybrid platform described here offers a solution for most peptide therapeutics that suffer from a short circulation half-life in blood. | * |
dc.language | English | * |
dc.publisher | WILEY-V C H VERLAG GMBH | * |
dc.subject | antibodies | * |
dc.subject | aptides | * |
dc.subject | cancer therapy | * |
dc.subject | fibronectin | * |
dc.subject | peptide therapeutics | * |
dc.title | A Hybrid Platform Based on a Bispecific Peptide-Antibody Complex for Targeted Cancer Therapy | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 58 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2005 | * |
dc.relation.lastpage | 2010 | * |
dc.relation.journaltitle | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | * |
dc.identifier.doi | 10.1002/anie.201811509 | * |
dc.identifier.wosid | WOS:000458828000021 | * |
dc.author.google | Yu, Byeongjun | * |
dc.author.google | Hwang, Dobeen | * |
dc.author.google | Jeon, Hyungsu | * |
dc.author.google | Kim, Hyungjun | * |
dc.author.google | Lee, Yonghyun | * |
dc.author.google | Keum, Hyeongseop | * |
dc.author.google | Kim, Jinjoo | * |
dc.author.google | Lee, Dong Yun | * |
dc.author.google | Kim, Yujin | * |
dc.author.google | Chung, Junho | * |
dc.author.google | Jon, Sangyong | * |
dc.contributor.scopusid | 이용현(38561637800) | * |
dc.date.modifydate | 20231214111942 | * |