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dc.contributor.author조제원-
dc.date.accessioned2020-08-20T16:30:17Z-
dc.date.available2020-08-20T16:30:17Z-
dc.date.issued2019-
dc.identifier.issn1226-2560-
dc.identifier.issn2093-8144-
dc.identifier.otherOAK-27637-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/255012-
dc.description.abstractThe thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency burst firing and single spike tonic firing has been implicated to have a key role in sensory modulation including pain. Of the two firing modes, burst firing, especially maintaining certain burst firing properties, was suggested to be critical in controlling nociceptive behaviors. Therefore, understanding the factors that influence burst firing properties would offer important insight into understanding sensory modulation. Using computational modeling, we investigated how the balance of excitatory and inhibitory inputs into a TC neuron influence TC bursting properties. We found that intensity of inhibitory inputs and the timing of excitatory input delivery control the dynamics of bursting properties. Then, to reflect a more realistic model, excitatory inputs delivered at different dendritic locations proximal, intermediate, or distal-of a TC neuron were also investigated. Interestingly excitatory input delivered into a distal dendrite, despite the furthest distance, had the strongest influence in shaping burst firing properties. suggesting that not all inputs equally contribute to modulating TC bursting properties. Overall, the results provide computational insights in understanding the detailed mechanism of the factors influencing temporal pattern of thalamic bursts.-
dc.languageEnglish-
dc.publisherKOREAN SOC BRAIN &amp-
dc.publisherNEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE-
dc.subjectComputational biology-
dc.subjectThalamus-
dc.subjectSensory gating-
dc.subjectT-Type Calcium Channels-
dc.titleA Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume28-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage568-
dc.relation.lastpage577-
dc.relation.journaltitleEXPERIMENTAL NEUROBIOLOGY-
dc.identifier.doi10.5607/en.2019.28.5.568-
dc.identifier.wosidWOS:000496478400003-
dc.author.googlePark, Sanggeon-
dc.author.googleSohn, Jeong-Woo-
dc.author.googleCho, Jeiwon-
dc.author.googleHuh, Yeowool-
dc.date.modifydate20200820143207-
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일반대학원 > 뇌·인지과학과 > Journal papers
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