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Risk factors of delayed isolation of patients with pulmonary tuberculosis
- Title
- Risk factors of delayed isolation of patients with pulmonary tuberculosis
- Authors
- Kim C.-J.; Kim Y.; Bae J.Y.; Kim A.; Kim J.; Son H.J.; Choi H.J.
- Ewha Authors
- 김유경; 최희정; 김충종; 배지윤
- SCOPUS Author ID
- 김유경; 최희정; 김충종; 배지윤
- Issue Date
- 2020
- Journal Title
- Clinical Microbiology and Infection
- ISSN
- 1198-743X
- Citation
- Clinical Microbiology and Infection vol. 26, no. 8, pp. 1058 - 1062
- Keywords
- Health personnel; Nosocomial; Occupational exposure; Risk factor tuberculosis
- Publisher
- Elsevier B.V.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objectives: The aim was to examine the rate of delayed or no isolation of hospitalized patients with pulmonary tuberculosis (TB) and the causes for isolation failure. Methods: This retrospective study included patients with pulmonary TB at a university-affiliated hospital in South Korea between January 2015 and June 2018 after excluding those with a stay ≤2 days and those who only visited the emergency department. Patients who were not isolated for ≥3 days were classified as the delayed or no isolation group. We compared the clinical findings and diagnostic test results, between patients managed with delayed or no isolation (D-isolation) and timely isolation (T-isolation). Results: Of 486 patients with pulmonary TB, 222 patients were included. In 106 cases (47.7%), isolation was delayed or not applied, while in 116 cases, isolation was applied in a timely manner. Typical findings of TB were seen on the chest X-rays of 87 (75.0%) patients in the T-isolation group versus 25 (23.6%) patients in the D-isolation group (p < 0.001). Other factors significantly associated with delayed or no isolation on univariate analyses were older age, admission route (emergency room vs. other), admitting department, negative acid-fast bacilli (AFB) stain, and negative MTB PCR. On multivariate analysis, admission through an outpatient clinic, admission to a department other than infectious diseases or pulmonology, an atypical chest X-ray finding and negative sputum AFB stains were risk factors for isolation failure. Discussion: Delayed or no isolation of patients with pulmonary TB was attributed mainly to atypical radiological findings and negative findings of direct TB diagnostic tests. © 2020
- DOI
- 10.1016/j.cmi.2020.01.032
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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