Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조제원 | * |
dc.date.accessioned | 2020-08-13T16:30:10Z | - |
dc.date.available | 2020-08-13T16:30:10Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0304-3940 | * |
dc.identifier.issn | 1872-7972 | * |
dc.identifier.other | OAK-27262 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254926 | - |
dc.description.abstract | The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesioned and sham-operated animals were subjected to either a brief 20-min restraint+ 20 tailshocks or a prolonged 60-min restraint+ 60 tailshocks. Post-stress performances in the object recognition memory and c-Fos immunoreactivity in the amygdala were then assessed. In sham-operated animals, the object recognition memory was reliably impaired following the prolonged, but not following the brief stress exposure. On the other hand, in mPFC-lesioned animals, the brief stress significantly impaired recognition memory and enhanced c-Fos expression in the amygdala. Present findings of loss of mPFC activity exacerbating stress effects provide causal evidence that the mPFC exerts inhibitory control on stress. | * |
dc.language | English | * |
dc.publisher | ELSEVIER IRELAND LTD | * |
dc.subject | Stress | * |
dc.subject | Medial prefrontal cortex | * |
dc.subject | Amygdala | * |
dc.subject | c-Fos | * |
dc.subject | Recognition memory | * |
dc.title | Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions | * |
dc.type | Article | * |
dc.relation.volume | 735 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NEUROSCIENCE LETTERS | * |
dc.identifier.doi | 10.1016/j.neulet.2020.135245 | * |
dc.identifier.wosid | WOS:000569396300009 | * |
dc.identifier.scopusid | 2-s2.0-85087705521 | * |
dc.author.google | Park, Jung-Cheol | * |
dc.author.google | Jeon, Yong-Jae | * |
dc.author.google | Kim, Jeansok J. | * |
dc.author.google | Cho, Jeiwon | * |
dc.author.google | Choi, Dong-Hee | * |
dc.author.google | Han, Jung-Soo | * |
dc.contributor.scopusid | 조제원(7403536141) | * |
dc.date.modifydate | 20240311133514 | * |