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Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions

Title
Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions
Authors
Park J.-C.Jeon Y.-J.Kim J.J.Cho J.Choi D.-H.Han J.-S.
Ewha Authors
조제원
Issue Date
2020
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
Neuroscience Letters vol. 735
Keywords
Amygdalac-FosMedial prefrontal cortexRecognition memoryStress
Publisher
Elsevier Ireland Ltd
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesioned and sham-operated animals were subjected to either a brief 20-min restraint+20 tailshocks or a prolonged 60-min restraint+60 tailshocks. Post-stress performances in the object recognition memory and c-Fos immunoreactivity in the amygdala were then assessed. In sham-operated animals, the object recognition memory was reliably impaired following the prolonged, but not following the brief stress exposure. On the other hand, in mPFC-lesioned animals, the brief stress significantly impaired recognition memory and enhanced c-Fos expression in the amygdala. Present findings of loss of mPFC activity exacerbating stress effects provide causal evidence that the mPFC exerts inhibitory control on stress. © 2020 Elsevier B.V.
DOI
10.1016/j.neulet.2020.135245
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일반대학원 > 뇌·인지과학과 > Journal papers
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