View : 1178 Download: 0
Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions
- Title
- Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions
- Authors
- Park, Jung-Cheol; Jeon, Yong-Jae; Kim, Jeansok J.; Cho, Jeiwon; Choi, Dong-Hee; Han, Jung-Soo
- Ewha Authors
- 조제원
- SCOPUS Author ID
- 조제원
- Issue Date
- 2020
- Journal Title
- NEUROSCIENCE LETTERS
- ISSN
- 0304-3940
1872-7972
- Citation
- NEUROSCIENCE LETTERS vol. 735
- Keywords
- Stress; Medial prefrontal cortex; Amygdala; c-Fos; Recognition memory
- Publisher
- ELSEVIER IRELAND LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesioned and sham-operated animals were subjected to either a brief 20-min restraint+ 20 tailshocks or a prolonged 60-min restraint+ 60 tailshocks. Post-stress performances in the object recognition memory and c-Fos immunoreactivity in the amygdala were then assessed. In sham-operated animals, the object recognition memory was reliably impaired following the prolonged, but not following the brief stress exposure. On the other hand, in mPFC-lesioned animals, the brief stress significantly impaired recognition memory and enhanced c-Fos expression in the amygdala. Present findings of loss of mPFC activity exacerbating stress effects provide causal evidence that the mPFC exerts inhibitory control on stress.
- DOI
- 10.1016/j.neulet.2020.135245
- Appears in Collections:
- 일반대학원 > 뇌·인지과학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML