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Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions
- Brief stress impairs recognition memory through amygdalar activation in animals with medial prefrontal cortex lesions
- Park J.-C.; Jeon Y.-J.; Kim J.J.; Cho J.; Choi D.-H.; Han J.-S.
- Ewha Authors
- Issue Date
- Journal Title
- Neuroscience Letters
- Neuroscience Letters vol. 735
- Amygdala; c-Fos; Medial prefrontal cortex; Recognition memory; Stress
- Elsevier Ireland Ltd
- SCIE; SCOPUS
- Document Type
- The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesioned and sham-operated animals were subjected to either a brief 20-min restraint+20 tailshocks or a prolonged 60-min restraint+60 tailshocks. Post-stress performances in the object recognition memory and c-Fos immunoreactivity in the amygdala were then assessed. In sham-operated animals, the object recognition memory was reliably impaired following the prolonged, but not following the brief stress exposure. On the other hand, in mPFC-lesioned animals, the brief stress significantly impaired recognition memory and enhanced c-Fos expression in the amygdala. Present findings of loss of mPFC activity exacerbating stress effects provide causal evidence that the mPFC exerts inhibitory control on stress. © 2020 Elsevier B.V.
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