Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정지향 | * |
dc.date.accessioned | 2020-08-13T16:30:09Z | - |
dc.date.available | 2020-08-13T16:30:09Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1758-9193 | * |
dc.identifier.other | OAK-27274 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254915 | - |
dc.description.abstract | Background: Recently, several studies suggested potential involvements of alpha-synuclein in Alzheimer's disease (AD) pathophysiology. Higher concentrations of alpha-synuclein were reported in cerebrospinal fluid (CSF) of AD patients with a positive correlation towards CSF tau, indicating its possible role in AD. We analyzed the CSF biomarkers to verify whether alpha-synuclein could be an additional supported biomarker in AD diagnosis. Methods: In this cross-sectional study, CSF samples of 71 early-onset AD, 34 late-onset AD, 11 mild cognitive impairment, 17 subjective cognitive decline, 45 Parkinson's disease, and 32 healthy control (HC) were collected. CSF amyloid-beta 1-42 (A), total tau (N), and phosphorylated tau181 (T) were measured by commercial ELISA kits, and in-house ELISA kit was developed to quantify alpha-synuclein. The cognitive assessments and amyloid-PET imaging were also performed. Results: CSF alpha-synuclein manifested a tendency to increase in AD and to decreased in Parkinson's disease compared to HC. The equilibrium states of total tau and alpha-synuclein concentrations were changed significantly in AD, and the ratio of total tau/alpha-synuclein (N/alpha S) was dramatically increased in AD than HC. Remarkably, N/alpha S revealed a strong positive correlation with tau phosphorylation rate. Also, the combination of N/alpha S with amyloid-beta 1-42/phosphorylated tau181 ratio had the best diagnosis performance (AUC = 0.956, sensitivity = 96%, specificity = 87%). In concordance analysis, N/alpha S showed the higher diagnostic agreement with amyloid-beta 1-42 and amyloid-PET. Analysis of biomarker profiling with N/alpha S had distinctive characteristics and clustering of each group. Especially, among the group of suspected non-Alzheimer's disease pathophysiology, all A-T+N+ patients with N/alpha S+ were reintegrated into AD. Conclusions: The high correlation of alpha-synuclein with tau and the elevated N/alpha S in AD supported the involvement of alpha-synuclein in AD pathophysiology. Importantly, N/alpha S improved the diagnostic performance, confirming the needs of incorporating alpha-synuclein as a biomarker for neurodegenerative disorders. The incorporation of a biomarker group [N/alpha S] could contribute to provide better understanding and diagnosis of neurodegenerative disorders. | * |
dc.language | English | * |
dc.publisher | BMC | * |
dc.subject | Alzheimer's disease | * |
dc.subject | Cerebrospinal fluid | * |
dc.subject | Tau | * |
dc.subject | alpha-Synuclein | * |
dc.subject | Biomarker | * |
dc.title | CSF total tau/alpha-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | ALZHEIMERS RESEARCH & THERAPY | * |
dc.identifier.doi | 10.1186/s13195-020-00648-9 | * |
dc.identifier.wosid | WOS:000552835800001 | * |
dc.identifier.scopusid | 2-s2.0-85088016172 | * |
dc.author.google | Shim, Kyu Hwan | * |
dc.author.google | Kang, Min Ju | * |
dc.author.google | Suh, Jee Won | * |
dc.author.google | Pyun, Jung-Min | * |
dc.author.google | Ryoo, Nayoung | * |
dc.author.google | Park, Young Ho | * |
dc.author.google | Youn, Young Chul | * |
dc.author.google | Jang, Jae-Won | * |
dc.author.google | Jeong, Jee Hyang | * |
dc.author.google | Park, Kyung Won | * |
dc.author.google | Choi, Seong Hye | * |
dc.author.google | Suk, Kyoungho | * |
dc.author.google | Lee, Ho-Won | * |
dc.author.google | Ko, Pan-Woo | * |
dc.author.google | Lee, Chan-Nyoung | * |
dc.author.google | Lim, Tae-Sung | * |
dc.author.google | An, Seong Soo A. | * |
dc.author.google | Kim, SangYun|Alzheimer's Dis All Markers ADAM R | * |
dc.contributor.scopusid | 정지향(7402045750;57192068764) | * |
dc.date.modifydate | 20240123101416 | * |