View : 536 Download: 0
Practical direct synthesis of N-aryl-substituted azacycles from N-alkyl protected arylamines using TiCl4 and DBU
- Title
- Practical direct synthesis of N-aryl-substituted azacycles from N-alkyl protected arylamines using TiCl4 and DBU
- Authors
- Van Hieu Tran; Minh Thanh La; Kang, Soosung; Kim, Hee-Kwon
- Ewha Authors
- 강수성
- SCOPUS Author ID
- 강수성
- Issue Date
- 2020
- Journal Title
- ORGANIC & BIOMOLECULAR CHEMISTRY
- ISSN
- 1477-0520
1477-0539
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY vol. 18, no. 26, pp. 5008 - 5016
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A novel transformation of N-alkyl protected arylamines and cyclic ethers into N-aryl substituted azacycles is described. Alkyl groups have been used for the protection of amines in organic syntheses. In this synthesis, N-alkyl protected arylamines were reacted with cyclic ethers in the presence of TiCl4 and DBU, crucial reagents affording five- and six-membered azacycles. In particular, utilization of the novel TiCl4/DBU-mediated reaction allows various N-alkyl protected arylamines such as N-methyl-, N-ethyl-, N-isopropyl, and N-tert-butyl arylamines to be readily converted into N-aryl substituted azacycles in high yields. This practical approach using various N-alkyl arylamines leads to the efficient preparation of azacycles.
- DOI
- 10.1039/d0ob00880j
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML