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Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

Title
Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry
Authors
Won, Ki-BumLee, Byoung KwonPark, Hyung-BokHeo, RanLee, Sang-EunRizvi, AsimLin, Fay Y.Kumar, AmitHadamitzky, MartinKim, Yong-JinSung, Ji MinConte, EdoardoAndreini, DanielePontone, GianlucaBudof, Matthew J.Gottlieb, IlanChun, Eun JuCademartiri, FilippoMafei, EricaMarques, HugoGoncalves, Pedro de AraujoLeipsic, Jonathon A.Shin, SanghoonChoi, Jung HyunVirmani, RenuSamady, HabibChinnaiyan, KavithaRaf, Gilbert L.Stone, Peter H.Berman, Daniel S.Narula, JagatShaw, Leslee J.Bax, Jeroen J.Min, James K.Chang, Hyuk-Jae
Ewha Authors
신상훈이상은
SCOPUS Author ID
신상훈scopus
Issue Date
2020
Journal Title
CARDIOVASCULAR DIABETOLOGY
ISSN
1475-2840JCR Link
Citation
CARDIOVASCULAR DIABETOLOGY vol. 19, no. 1
Keywords
Triglyceride glucose indexCoronary artery diseaseAtherosclerosisCoronary computed tomography angiography
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods A total of 1143 subjects (aged 60.7 +/- 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm(3)) at follow-up minus PV at index > 0. Annual change of PV (mm(3)/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) >= 1.0%/year. Results The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. Conclusion TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registrationClinicalTrials.gov NCT02803411
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DOI
10.1186/s12933-020-01081-w
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의료원 > 의료원 > Journal papers
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