Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 박주원 | * |
dc.contributor.author | 김유희 | * |
dc.contributor.author | 조경아 | * |
dc.contributor.author | 우경제 | * |
dc.date.accessioned | 2020-08-13T16:30:07Z | - |
dc.date.available | 2020-08-13T16:30:07Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1107-3756 | * |
dc.identifier.issn | 1791-244X | * |
dc.identifier.other | OAK-27294 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254899 | - |
dc.description.abstract | Bone marrow (BM) transplantation (BMT) represents a curative treatment for various hematological disorders. Prior to BMT, a large amount of the relevant anticancer drug needed to be administered to eliminate cancer cells. However, during this pre-BMT cytotoxic conditioning regimen, hematopoietic stem cells in the BM and thymic epithelial cells were also destroyed. The T cell receptor (TCR) recognizes diverse pathogen, tumor and environmental antigens, and confers immunological memory and self-tolerance. Delayed thymus reconstitution following pre-BMT cytotoxic conditioning impedesde novothymopoiesis and limits T cell-mediated immunity. Several cytokines, such as RANK ligand, interleukin (IL)-7, IL-22 and stem cell factor, were recently reported to improve thymopoiesis and immune function following BMT. In the present study, it was found that the co-transplantation of tonsil-derived mesenchymal stromal cells (T-MSCs) with BM-derived cells (BMCs) accelerated the recovery of involuted thymuses in mice following partial pre-BMT conditioning with busulfan-cyclophosphamide treatment, possibly by inducing FMS-like tyrosine kinase 3 ligand (FLT3L) and fibroblast growth factor 7 (FGF7) production in T-MSCs. The co-transplantation of T-MSCs with BMCs also replenished the CD3(+)cell population by inhibiting thymocyte apoptosis following pre-BMT cytotoxic conditioning. Furthermore, T-MSC co-transplantation improved the recovery of the TCR repertoire and led to increased thymus-generated T cell diversity. | * |
dc.language | English | * |
dc.publisher | SPANDIDOS PUBL LTD | * |
dc.subject | tonsil-derived mesenchymal stromal cells | * |
dc.subject | bone marrow transplantation | * |
dc.subject | thymus | * |
dc.subject | T cell diversity | * |
dc.title | Co-transplantation of tonsil-derived mesenchymal stromal cells in bone marrow transplantation promotes thymus regeneration and T cell diversity following cytotoxic conditioning | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1166 | * |
dc.relation.lastpage | 1174 | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | * |
dc.identifier.doi | 10.3892/ijmm.2020.4657 | * |
dc.identifier.wosid | WOS:000562767700024 | * |
dc.identifier.scopusid | 2-s2.0-85088490828 | * |
dc.author.google | Choi, Da-Won | * |
dc.author.google | Cho, Kyung-Ah | * |
dc.author.google | Lee, Hyun-Ji | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Woo, Kyong-Je | * |
dc.author.google | Park, Joo-Won | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.author.google | Woo, So-Youn | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 박주원(8656832200) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.contributor.scopusid | 우경제(35319271600) | * |
dc.date.modifydate | 20240429113726 | * |