Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2020-08-13T16:30:07Z | - |
dc.date.available | 2020-08-13T16:30:07Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0045-2068 | * |
dc.identifier.issn | 1090-2120 | * |
dc.identifier.other | OAK-27297 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254896 | - |
dc.description.abstract | Bioassay-guided fractionation of a 90% ethanol extract of Periostracum Cicadae led to the isolation of two new N-acetyldopamine dimers (1a/1b) along with six known dimers (2a/2b, 3a/3b, and 4a/4b) and two monomers (5a/5b); compounds 2a/2b, 4a/4b and 5a/5b were newly isolated from this material. All compounds were isolated as enantiomeric mixtures and each enantiomer was successfully separated by chiral-phase HPLC. The structures including absolute configurations were confirmed by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), 1D/2D nuclear magnetic resonance (NMR) spectroscopy, H-1 iterative Full Spin Analysis (HiFSA), and electronic circular dichroism (ECD) spectroscopy. Subsequently, the bioactivities of these isolates were evaluated via CD4(+) T cell differentiations, which are critical for immune responses and inflammation. The results revealed that compound 5b was observed to enhance the IFN-gamma(+) Th1 differentiation, which may have a potential for cancer immunotherapy. | * |
dc.language | English | * |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | * |
dc.subject | Periostracum Cicadae | * |
dc.subject | N-acetyldopamine dimers | * |
dc.subject | H-1 iterative Full Spin Analysis (HiFSA) | * |
dc.subject | Electronic circular dichroism (ECD) calculation | * |
dc.subject | CD4(+) T cell | * |
dc.title | N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation | * |
dc.type | Article | * |
dc.relation.volume | 102 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BIOORGANIC CHEMISTRY | * |
dc.identifier.doi | 10.1016/j.bioorg.2020.104095 | * |
dc.identifier.wosid | WOS:000565187500005 | * |
dc.identifier.scopusid | 2-s2.0-85088517318 | * |
dc.author.google | Thapa, Punam | * |
dc.author.google | Gu, Ye | * |
dc.author.google | Kil, Yun-Seo | * |
dc.author.google | Baek, Su Cheol | * |
dc.author.google | Kim, Ki Hyun | * |
dc.author.google | Han, Ah-Reum | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.author.google | Choi, Hyukjae | * |
dc.author.google | Chang, Jae-Hoon | * |
dc.author.google | Nam, Joo-Won | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |