Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 백승연 | * |
dc.contributor.author | 유권 | * |
dc.contributor.author | 이정경 | * |
dc.contributor.author | 김태헌 | * |
dc.contributor.author | 최선영 | * |
dc.contributor.author | 김휘영 | * |
dc.contributor.author | 이혜아 | * |
dc.contributor.author | 남준열 | * |
dc.contributor.author | 최아름 | * |
dc.date.accessioned | 2020-07-16T16:30:12Z | - |
dc.date.available | 2020-07-16T16:30:12Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1471-2407 | * |
dc.identifier.other | OAK-27189 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254203 | - |
dc.description.abstract | Background The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring system to guide TACE initiation/repetition. Methods A total of 597 consecutive patients who underwent TACE as their initial treatment for unresectable HCC were included. We derived a prediction model using independent risk factors for overall survival (OS), which was externally validated in an independent cohort (n = 739). Results Independent risk factors of OS included Albumin-bilirubin (ALBI) grade, maximal tumor size, alpha-fetoprotein, and tumor response to initial TACE, which were used to develop a scoring system ("ASAR"). C-index values for OS were 0.733 (95% confidence interval [CI] = 0.570-0.871) in the derivation, 0.700 (95% CI = 0.445-0.905) in the internal validation, and 0.680 (95% CI = 0.652-0.707) in the external validation, respectively. Patients with ASAR< 4 showed significantly longer OS than patients with ASAR >= 4 in all three datasets (all P < 0.001). Among Child-Pugh class B patients, a modified model without TACE response, i.e., "ASA(R)", discriminated OS with a c-index of 0.788 (95% CI, 0.703-0.876) in the derivation, and 0.745 (95% CI, 0.646-0.862) in the internal validation, and 0.670 (95% CI, 0.605-0.725) in the external validation, respectively. Child-Pugh B patients with ASA(R) < 4 showed significantly longer OS than patients with ASA(R) >= 4 in all three datasets (all P < 0.001). Conclusions ASAR provides refined prognostication for repetition of TACE in patients with unresectable HCC. For Child-Pugh class B patients, a modified model with baseline factors might guide TACE initiation. | * |
dc.language | English | * |
dc.publisher | BMC | * |
dc.subject | Hepatocellular carcinoma | * |
dc.subject | Transarterial chemoembolization | * |
dc.subject | Child-Pugh classification | * |
dc.subject | Risk prediction model | * |
dc.title | A differential risk assessment and decision model for Transarterial chemoembolization in hepatocellular carcinoma based on hepatic function | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BMC CANCER | * |
dc.identifier.doi | 10.1186/s12885-020-06975-2 | * |
dc.identifier.wosid | WOS:000538120900003 | * |
dc.author.google | Nam, Joon Yeul | * |
dc.author.google | Choe, A. Reum | * |
dc.author.google | Sinn, Dong Hyun | * |
dc.author.google | Lee, Jeong-Hoon | * |
dc.author.google | Kim, Hwi Young | * |
dc.author.google | Yu, Su Jong | * |
dc.author.google | Kim, Yoon Jun | * |
dc.author.google | Yoon, Jung-Hwan | * |
dc.author.google | Lee, Jeong Min | * |
dc.author.google | Chung, Jin Wook | * |
dc.author.google | Choi, Sun Young | * |
dc.author.google | Lee, Jeong Kyong | * |
dc.author.google | Baek, Seung Yon | * |
dc.author.google | Lee, Hye Ah | * |
dc.author.google | Kim, Tae Hun | * |
dc.author.google | Yoo, Kwon | * |
dc.contributor.scopusid | 백승연(7201371530) | * |
dc.contributor.scopusid | 유권(7202592827) | * |
dc.contributor.scopusid | 이정경(35316081600) | * |
dc.contributor.scopusid | 김태헌(57125156300;57219781484) | * |
dc.contributor.scopusid | 최선영(57207282104;55736572600) | * |
dc.contributor.scopusid | 김휘영(56493773500) | * |
dc.contributor.scopusid | 이혜아(57188947704) | * |
dc.contributor.scopusid | 남준열(57193006895) | * |
dc.contributor.scopusid | 최아름(57190020909) | * |
dc.date.modifydate | 20240429140130 | * |