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Verification of the performance of the BD MAX Check-Points CPO Assay on clinical isolates

Title
Verification of the performance of the BD MAX Check-Points CPO Assay on clinical isolates
Authors
Chung, Hae-SunLee, Miae
Ewha Authors
이미애정혜선
SCOPUS Author ID
이미애scopus; 정혜선scopus
Issue Date
2020
Journal Title
JOURNAL OF LABORATORY MEDICINE
ISSN
2567-9430JCR Link

2567-9449JCR Link
Citation
JOURNAL OF LABORATORY MEDICINE vol. 44, no. 3, pp. 165 - 168
Keywords
BD MAX Check-Points CPO AssaycarbapenemaseEnterobacteriaceaereal-time PCR
Publisher
WALTER DE GRUYTER GMBH
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objectives: The BD MAX Check-Points CPO Assay (BD MAX CPO Assay; BD, The Netherlands) is a diagnostic test designed for the rapid detection and differentiation of the bla(KPC), bla(NDM), bla(VIM)/bla(IMP-1),and bla(OXA-48) genes. We verified the performance of the BD MAX CPO Assay to implement it in the clinical laboratory. Methods: A total of 113 bacterial isolates collected from various clinical specimens harboring carbapenemase genes as confirmed by polymerase chain reaction (PCR) and sequencing were evaluated. The results of the BD MAX CPO Assay were compared to previously confirmed results. Results: All results of the BD MAX CPO Assay were concordant with previous results; 61 Klebsiella pneumoniae carbapenemase (KPC), 40 New Delhi metallo-beta-lactamase (NDM), three oxacillinase-48 (OXA-48)-like, two imipenem (IMP), and four multiple carbapenemase genes (one KPC/NDM, three NDM/OXA) were detected by the BD MAX CPO Assay. Three non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae isolates were negative. Conclusions: The BD MAX CPO Assay can be used to identify carbapenemase gene in bacterial isolates cultured from clinical specimens in the clinical laboratory.
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DOI
10.1515/labmed-2019-0145
Appears in Collections:
의과대학 > 의학과 > Journal papers
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