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A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria
- Title
- A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria
- Authors
- Lee, Eunhye; Li, Xingshu; Oh, Juwon; Kwon, Nahyun; Kim, Gyoungmi; Kim, Dongho; Yoon, Juyoung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2020
- Journal Title
- CHEMICAL SCIENCE
- ISSN
- 2041-6520
2041-6539
- Citation
- CHEMICAL SCIENCE vol. 11, no. 22, pp. 5735 - 5739
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.
- DOI
- 10.1039/d0sc01351j
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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