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Airflow limitation as a risk factor for vascular stiffness

Title
Airflow limitation as a risk factor for vascular stiffness
Authors
Sheen, S. S.Kim, H. J.Singh, D.Hwang, S. C.Park, K. J.Ahn, S. V.Lee, E.Park, B.Jung, J. H.Park, R. W.Kim, J. H.Park, H-S.Park, J. H.
Ewha Authors
안성복
SCOPUS Author ID
안성복scopus
Issue Date
2020
Journal Title
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
ISSN
1027-3719JCR Link

1815-7920JCR Link
Citation
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE vol. 24, no. 6, pp. 577 - +
Keywords
airflow limitationatherosclerosissmoking
Publisher
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
BACKGROUND: Cardiovascular disease is one of the main causes of mortality in patients with chronic obstructive pulmonary disease (COPD), and atherosclerosis is a cause of cardiac comorbidities in COPD. However, it is not clear whether airflow limitation is associated with atherosclerosis irrespective of smoking. OBJECTIVE: To investigate whether airflow limitation is independently associated with vascular stiffness. METHODS: We enrolled 18 893 participants (male 70.5%; mean age 47.5 +/- 9.8 years; never smokers 44.2%) who underwent spirometry and brachial-ankle pulse wave velocity (baPWV) as part of a standard health examination at Ajou University Hospital, Suwon, South Korea, from January 2010 to December 2015. We defined vascular peripheral atherosclerosis as baPWV >= 1400 cm/s and airflow limitation as pre-bronchodilator ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity (FVC) >70%. RESULTS: Mean baPWV was higher in subjects with airflow limitation (1477.6 +/- 331.7 cm/sec, n = 638) than in those without airflow limitation (1344.1 +/- 231.8 cm/sec, n = 18255, P < 0.001). In multivariate logistic regression analysis, the following were independent predictors associated with peripheral atherosclerosis (P < 0.05): age, male sex, fasting serum glucose, mean blood pressure, serum leukocyte count, serum low density lipoprotein level and FEV1. CONCLUSION: Airflow limitation was an independent predictor of vascular stiffness irrespective of smoking history, which suggests that airflow limitation is linked with atherosclerosis.
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DOI
10.5588/ijtld.19.0457
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신산업융합대학 > 융합보건학과 > Journal papers
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