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Airflow limitation as a risk factor for vascular stiffness
- Airflow limitation as a risk factor for vascular stiffness
- Sheen, S. S.; Kim, H. J.; Singh, D.; Hwang, S. C.; Park, K. J.; Ahn, S. V.; Lee, E.; Park, B.; Jung, J. H.; Park, R. W.; Kim, J. H.; Park, H-S.; Park, J. H.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE vol. 24, no. 6, pp. 577 - +
- airflow limitation; atherosclerosis; smoking
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
- SCIE; SCOPUS
- Document Type
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- BACKGROUND: Cardiovascular disease is one of the main causes of mortality in patients with chronic obstructive pulmonary disease (COPD), and atherosclerosis is a cause of cardiac comorbidities in COPD. However, it is not clear whether airflow limitation is associated with atherosclerosis irrespective of smoking. OBJECTIVE: To investigate whether airflow limitation is independently associated with vascular stiffness. METHODS: We enrolled 18 893 participants (male 70.5%; mean age 47.5 +/- 9.8 years; never smokers 44.2%) who underwent spirometry and brachial-ankle pulse wave velocity (baPWV) as part of a standard health examination at Ajou University Hospital, Suwon, South Korea, from January 2010 to December 2015. We defined vascular peripheral atherosclerosis as baPWV >= 1400 cm/s and airflow limitation as pre-bronchodilator ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity (FVC) >70%. RESULTS: Mean baPWV was higher in subjects with airflow limitation (1477.6 +/- 331.7 cm/sec, n = 638) than in those without airflow limitation (1344.1 +/- 231.8 cm/sec, n = 18255, P < 0.001). In multivariate logistic regression analysis, the following were independent predictors associated with peripheral atherosclerosis (P < 0.05): age, male sex, fasting serum glucose, mean blood pressure, serum leukocyte count, serum low density lipoprotein level and FEV1. CONCLUSION: Airflow limitation was an independent predictor of vascular stiffness irrespective of smoking history, which suggests that airflow limitation is linked with atherosclerosis.
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