View : 198 Download: 0

Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging

Title
Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging
Authors
Nguyen, Van-NghiaYim, YubinKim, SanginRyu, BokyeongSwamy, K. M. K.Kim, GyoungmiKwon, NahyunKim, C-YoonPark, SungnamYoon, Juyoung
Ewha Authors
윤주영K.M.K SwamyNguyen Van Nghia
SCOPUS Author ID
윤주영scopus; K.M.K Swamyscopus; Nguyen Van Nghiascopus
Issue Date
2020
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851JCR Link

1521-3773JCR Link
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION vol. 59, no. 23, pp. 8957 - 8962
Keywords
aggregation-induced emissionBODIPYheavy-atom-free photosensitizersphotodynamic therapyreactive oxygen species
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Novel BODIPY photosensitizers were developed for imaging-guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a phenyl linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap between the lowest singlet excited state and the lowest triplet state (Delta E-ST), leading to a significant enhancement in the intersystem crossing (ISC) of the BODIPYs. Remarkably, the BDP-5 with the smallest Delta E-ST (ca. 0.44 eV) exhibited excellent singlet oxygen generation capabilities in both organic and aqueous solutions. BDP-5 also displayed bright emission in the far-red/near-infrared region in the condensed states. More importantly, both in vitro and in vivo studies demonstrated that BDP-5 NPs displayed a high potential for photodynamic cancer therapy and bioimaging.
Show the fulltext
DOI
10.1002/anie.202002843
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE