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The Relationship between Serum Vitamin D Levels, C-Reactive Protein, and Anxiety Symptoms

Title
The Relationship between Serum Vitamin D Levels, C-Reactive Protein, and Anxiety Symptoms
Authors
Kim, Sun-YoungJeon, Sang-WonLim, Weon-JeongOh, Kang-SeobShin, Dong-WonCho, Sung JoonPark, Jae-HyunShin, Young-Chul
Ewha Authors
임원정김선영
SCOPUS Author ID
임원정scopus
Issue Date
2020
Journal Title
PSYCHIATRY INVESTIGATION
ISSN
1738-3684JCR Link

1976-3026JCR Link
Citation
PSYCHIATRY INVESTIGATION vol. 17, no. 4, pp. 312 - 319
Keywords
Vitamin DCRPAnxiety
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Indexed
SCIE; SSCI; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Objective The aim of study is to investigate the relationship between serum vitamin D, c-reactive protein (CRP) levels, and anxiety symptoms. Methods Serum vitamin D and CRP levels of 51,003 Korean adult participants were collected retrospectively. Anxiety symptoms were assessed using the Korean version of Beck Anxiety Inventory. Logistic regression was used to estimate the odds ratio (ORs) of anxiety symptoms by serum vitamin D and CRP levels. The regression was adjusted for covariates, and each model was adjusted mutually for vitamin D and CRP levels. Results Compared with sufficient vitamin D levels (>= 20 ng/mL), insufficient (10-19.99 ng/mL) and deficient (<10 ng/mL) vitamin D levels were significantly associated with risk of anxiety symptoms. Also, continuous vitamin D levels were negatively associated with the risk of anxiety symptoms. CRP levels did not affect the relationship between vitamin D levels and risk of anxiety symptoms. Conclusion Insufficient (10-19.99 ng/mL) and deficient (<10 ng/mL) vitamin D levels were significantly associated with risk of anxiety symptoms. After adjusting for CRP levels, the results were not changed, and no evidence of interaction between vitamin D and CRP levels was found. CRP levels did not account for the association between vitamin D levels and risk of anxiety symptoms.
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DOI
10.30773/pi.2019.0290
Appears in Collections:
의과대학 > 의학과 > Journal papers
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