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Redox regulation of tumor suppressor PTEN in cell signaling
- Title
- Redox regulation of tumor suppressor PTEN in cell signaling
- Authors
- Zhang, Ying; Park, Jiyoung; Han, Seong-Jeong; Yang, Sung Yeul; Yoon, Hyun Joong; Park, Iha; Woo, Hyun Ae; Lee, Seung-Rock
- Ewha Authors
- 우현애
- SCOPUS Author ID
- 우현애
- Issue Date
- 2020
- Journal Title
- REDOX BIOLOGY
- ISSN
- 2213-2317
- Citation
- REDOX BIOLOGY vol. 34
- Keywords
- PTEN; Redox regulation; Peroxides; Trx dimerization; Prx dimerization; Prx hyperoxidation
- Publisher
- ELSEVIER
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active -site cysteine by reactive oxygen species (ROS). Recovery of its enzymatic activity predominantly depends on the availability of cellular thioredoxin (Trx) and peroxiredoxins (Prx), both are important players in cell signaling. Trx and Prx undergo redox-dependent conformational changes through the oxidation of cysteine residues at their active sites. Their dynamics are essential for protein functionality and regulation. In this review, we summarized the recent ad- vances regarding the redox regulation of PTEN, with a specific focus on our current state-of-the-art under- standing of the redox regulation of PTEN. We also proposed a tight association of the redox regulation of PTEN with Trx dimerization and Prx hyperoxidation, providing guidance for the identification of novel therapeutic targets.
- DOI
- 10.1016/j.redox.2020.101553
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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