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Redox regulation of tumor suppressor PTEN in cell signaling

Title
Redox regulation of tumor suppressor PTEN in cell signaling
Authors
Zhang, YingPark, JiyoungHan, Seong-JeongYang, Sung YeulYoon, Hyun JoongPark, IhaWoo, Hyun AeLee, Seung-Rock
Ewha Authors
우현애
SCOPUS Author ID
우현애scopus
Issue Date
2020
Journal Title
REDOX BIOLOGY
ISSN
2213-2317JCR Link
Citation
REDOX BIOLOGY vol. 34
Keywords
PTENRedox regulationPeroxidesTrx dimerizationPrx dimerizationPrx hyperoxidation
Publisher
ELSEVIER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active -site cysteine by reactive oxygen species (ROS). Recovery of its enzymatic activity predominantly depends on the availability of cellular thioredoxin (Trx) and peroxiredoxins (Prx), both are important players in cell signaling. Trx and Prx undergo redox-dependent conformational changes through the oxidation of cysteine residues at their active sites. Their dynamics are essential for protein functionality and regulation. In this review, we summarized the recent ad- vances regarding the redox regulation of PTEN, with a specific focus on our current state-of-the-art under- standing of the redox regulation of PTEN. We also proposed a tight association of the redox regulation of PTEN with Trx dimerization and Prx hyperoxidation, providing guidance for the identification of novel therapeutic targets.
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DOI
10.1016/j.redox.2020.101553
Appears in Collections:
약학대학 > 약학과 > Journal papers
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