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Inhibition of African swine fever virus protease by myricetin and myricitrin
- Title
- Inhibition of African swine fever virus protease by myricetin and myricitrin
- Authors
- Jo, Seri; Kim, Suwon; Shin, Dong Hae; Kim, Mi-Sun
- Ewha Authors
- 신동해; 김수원; 김미선
- SCOPUS Author ID
- 신동해; 김수원; 김미선
- Issue Date
- 2020
- Journal Title
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- ISSN
- 1475-6366
1475-6374
- Citation
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY vol. 35, no. 1, pp. 1045 - 1049
- Keywords
- African swine fever virus protease; antiviral; flavonoid; fret; inhibitory compounds
- Publisher
- TAYLOR &
FRANCIS LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- African swine fever (ASF) caused by the ASF virus (ASFV) is the most hazardous swine disease. Since a huge number of pigs have been slaughtered to avoid a pandemic spread, intense studies on the disease should be followed quickly. Recent studies reported that flavonoids have various antiviral activity including ASFV. In this report, ASFV protease was selected as an antiviral target protein to cope with ASF. With a FRET (Fluorescence resonance energy transfer) method, ASFV protease was assayed with a flavonoid library which was composed of sixty-five derivatives classified based on ten different scaffolds. Of these, the flavonols scaffold contains a potential anti-ASFV protease activity. The most prominent flavonol was myricetin with IC50 of 8.4 mu M. Its derivative, myricitrin, with the rhamnoside moiety was also showed the profound inhibitory effect on ASFV protease. These two flavonols apparently provide a way to develop anti-ASFV agents based on their scaffold.
- DOI
- 10.1080/14756366.2020.1754813
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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