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dc.contributor.author우현애-
dc.date.accessioned2020-04-13T16:32:23Z-
dc.date.available2020-04-13T16:32:23Z-
dc.date.issued2020-
dc.identifier.issn0891-5849-
dc.identifier.issn1873-4596-
dc.identifier.otherOAK-26781-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/253829-
dc.description.abstractPeroxiredoxins (Prxs) are an unusual family of thiol-specific peroxidases that possess a binding site for H 2 O 2 and rely on a conserved cysteine residue for rapid reaction with H 2 O 2 . Among 6 mammalian isoforms (Prx I to VI), Prx I and Prx II are mainly found in the cytosol and nucleus. Prx I and Prx II function as antioxidant enzymes and protein chaperone under oxidative distress conditions. Under oxidative eustress conditions, Prx I and Prx II regulate the levels of H 2 O 2 at specific area of the cells as well as sense and transduce H 2 O 2 signaling to target proteins. Prx I and Prx II are known to be covalently modified on multiple sites: Prx I is hyperoxidized on Cys 52 ; phosphorylated on Ser 32 , Thr 90 , and Tyr 194 ; acetylated on Lys 7 , Lys 16 , Lys 27 , Lys 35 , and Lys 197 ; glutathionylated on Cys 52 , Cys 83 , and Cys 173 ; and nitrosylated on Cys 52 and Cys 83 , whereas Prx II is hyperoxidized on Cys 51 ; phosphorylated on Thr 89 , Ser 112 , and Thr 182 ; acetylated on Ala 2 and Lys 196 ; glutathionylated on Cys 51 and Cys 172 ; and nitrosylated on Cys 51 and Cys 172 . In this review, we describe how these post -translational mod- ifications affect various functions of Prx I and Prx II.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE INC-
dc.subjectPeroxiredoxin-
dc.subjectPeroxidase-
dc.subjectChaperone-
dc.subject2 O 2 )-
dc.subjectIntracellular messenger-
dc.subjectThiol oxidation-
dc.subjectPhosphorylation-
dc.subjectAcetylation-
dc.subjectGlutathionylation-
dc.subjectS-Nitrosylation-
dc.titleMultiple functions of 2-Cys peroxiredoxins, I and II, and their regulations via post -translational modifications-
dc.typeArticle-
dc.relation.volume152-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage107-
dc.relation.lastpage115-
dc.relation.journaltitleFREE RADICAL BIOLOGY AND MEDICINE-
dc.identifier.wosidWOS:000542921200003-
dc.identifier.scopusid2-s2.0-85081310780-
dc.author.googleRhee, Sue Goo-
dc.author.googleWoo, Hyun Ae-
dc.contributor.scopusid우현애(8068619500)-
dc.date.modifydate20200715111627-
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약학대학 > 약학과 > Journal papers
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