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Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD
- Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD
- Kim, Changhwan; Ko, Yousang; Jung, Ji Ye; Lee, Jae Seung; Rhee, Chin Kook; Lee, Jin Hwa; Lee, Ji-Hyun; Moon, Ji-Yong; Lim, Seong Yong; Yoo, Kwang Ha; Seo, Joon Beom; Oh, Yeon-Mok; Lee, Sang-Do; Park, Yong Bum
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- RESPIRATORY MEDICINE
- RESPIRATORY MEDICINE vol. 163
- Chronic obstructive pulmonary disease; Emphysema; Vitamin D
- W B SAUNDERS CO LTD
- SCIE; SCOPUS
- Document Type
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- Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of vitamin D deficiency. Vitamin D levels also correlate with lung function in patients with COPD. However, there are few reports on vitamin D deficiency and emphysema severity in COPD. This study aimed to investigate the effects of plasma 25-hydroxyvitamin D (25-OHD) level on emphysema severity in male COPD patients. Methods: A total of 151 male subjects were selected from the Korean Obstructive Lung Disease (KOLD) cohort. Subjects were subdivided into four subgroups according to their baseline plasma 25-OHD level: sufficiency (>= 20 ng/ml), mild deficiency (15-20 ng/ml), moderate deficiency (10-15 ng/ml), and severe deficiency (<10 ng/ml). Results: Baseline computed tomography (CT) emphysema indices revealed significant differences among the subgroups (p = 0.034). A statistically significant difference was also observed among the subgroups regarding change in the CT emphysema index over 3 years (p = 0.047). The annual increase in emphysema index was more prominent in the severe deficiency group (1.34% per year) than in the other groups (0.41% per year) (p = 0.003). Conclusions: This study demonstrates that CT emphysema indices were different among the four subgroups and supports that severe vitamin D deficiency is associated with rapid progression of emphysema in male patients with COPD.
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