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Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD

Title
Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD
Authors
Kim C.Ko Y.Jung J.Y.Lee J.S.Rhee C.K.Lee J.H.Lee J.-H.Moon J.-Y.Lim S.Y.Yoo K.H.Seo J.B.Oh Y.-M.Lee S.-D.Park Y.B.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2020
Journal Title
Respiratory Medicine
ISSN
0954-6111JCR Link
Citation
Respiratory Medicine vol. 163
Keywords
Chronic obstructive pulmonary diseaseEmphysemaVitamin D
Publisher
W.B. Saunders Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of vitamin D deficiency. Vitamin D levels also correlate with lung function in patients with COPD. However, there are few reports on vitamin D deficiency and emphysema severity in COPD. This study aimed to investigate the effects of plasma 25-hydroxyvitamin D (25-OHD) level on emphysema severity in male COPD patients. Methods: A total of 151 male subjects were selected from the Korean Obstructive Lung Disease (KOLD) cohort. Subjects were subdivided into four subgroups according to their baseline plasma 25-OHD level: sufficiency (≥20 ng/ml), mild deficiency (15–20 ng/ml), moderate deficiency (10–15 ng/ml), and severe deficiency (<10 ng/ml). Results: Baseline computed tomography (CT) emphysema indices revealed significant differences among the subgroups (p = 0.034). A statistically significant difference was also observed among the subgroups regarding change in the CT emphysema index over 3 years (p = 0.047). The annual increase in emphysema index was more prominent in the severe deficiency group (1.34% per year) than in the other groups (0.41% per year) (p = 0.003). Conclusions: This study demonstrates that CT emphysema indices were different among the four subgroups and supports that severe vitamin D deficiency is associated with rapid progression of emphysema in male patients with COPD. © Elsevier Ltd
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DOI
10.1016/j.rmed.2020.105890
Appears in Collections:
의과대학 > 의학과 > Journal papers
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