View : 189 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author윤주영-
dc.date.accessioned2020-03-23T16:30:15Z-
dc.date.available2020-03-23T16:30:15Z-
dc.date.issued2020-
dc.identifier.issn0143-7208-
dc.identifier.otherOAK-26595-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/253607-
dc.description.abstractA novel sulfur-substituted naphthalimide (LSNI-S) was synthesized and investigated as a promising lysosome-targeting photosensitizer for photodynamic cancer therapy. The introduction of a dual-functional morpholine group to the 4-position of the naphthalimide backbone combined with the substitution of oxygen atoms by sulfur atoms could facilitate intersystem crossing from the excited singlet state to the reactive triplet state, leading to an excellent singlet oxygen generation efficiency of LSNI-S in organic solvents (ΦΔ ≈ 0.84 in air-saturated acetonitrile). Interestingly, LSNI-S could produce reactive oxygen species via both type-I and type-II mechanisms under physiological conditions. In particular, cell studies demonstrated that LSNI-S selectively localizes in lysosomes of cancer cells and exhibits excellent photodynamic therapy efficacy. © 2020 Elsevier Ltd-
dc.languageEnglish-
dc.publisherElsevier Ltd-
dc.subjectHeavy-atom-free photosensitizer-
dc.subjectIntersystem crossing-
dc.subjectPhotodynamic therapy-
dc.subjectReactive oxygen species-
dc.subjectSulfur-substituted naphthalimide-
dc.titleA lysosome-localized thionaphthalimide as a potential heavy-atom-free photosensitizer for selective photodynamic therapy-
dc.typeArticle-
dc.relation.volume177-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleDyes and Pigments-
dc.identifier.doi10.1016/j.dyepig.2020.108265-
dc.identifier.wosidWOS:000525303800016-
dc.identifier.scopusid2-s2.0-85079357559-
dc.author.googleNguyen V.-N.-
dc.author.googleBaek G.-
dc.author.googleQi S.-
dc.author.googleHeo S.-
dc.author.googleYim Y.-
dc.author.googleYoon J.-
dc.contributor.scopusid윤주영(7403587371)-
dc.date.modifydate20200709163008-
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE