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Noninvasive indices for predicting nonalcoholic fatty liver disease in patients with chronic kidney disease

Title
Noninvasive indices for predicting nonalcoholic fatty liver disease in patients with chronic kidney disease
Authors
Choe, A. ReumRyu, Dong-RyeolKim, Hwi YoungLee, Hye AhLim, JiyoungKim, Jin SilLee, Jeong KyongKim, Tae HunYoo, Kwon
Ewha Authors
유권이정경김태헌류동열김휘영임지영김진실이혜아
SCOPUS Author ID
유권scopus; 이정경scopus; 김태헌scopusscopus; 류동열scopusscopusscopus; 김휘영scopus; 임지영scopus; 김진실scopus; 이혜아scopus
Issue Date
2020
Journal Title
BMC NEPHROLOGY
ISSN
1471-2369JCR Link
Citation
BMC NEPHROLOGY vol. 21, no. 1
Keywords
Chronic kidney diseaseNonalcoholic fatty liver diseaseNoninvasive markersPrediction model
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background Data on clinical characteristics of nonalcoholic fatty liver disease (NAFLD) in patients with chronic kidney disease (CKD) are scarce. We investigated the clinical features and risk factors of NAFLD using noninvasive serum markers in CKD patients and attempted the temporal validation of a predictive model for CKD based on NAFLD. Methods This retrospective cross-sectional study was conducted in a single tertiary center. We enrolled 819 CKD patients and evaluated the predictive performance of relevant clinical and laboratory markers for the presence of NAFLD in both derivation (data from 2011 to 2014, n = 567) and validation (data from 2015 to 2016, n = 252) groups. Results In the derivation group, NAFLD was observed in 89 patients (15.7%; mean body mass index (BMI), 24.6 kg/m(2); median estimated glomerular filtration rate (eGFR), 28.0 ml/min). BMI, hemoglobin, serum alanine aminotransferase, eGFR, and triglyceride-glucose index were used to derive a prediction model for the presence of NAFLD. Using the cutoff value of 0.146, the area under the receiver operating characteristic curve (AUROC) for the prediction of NAFLD was 0.850. In the validation group, NAFLD was observed in 51 patients (20.2%; mean BMI, 25.4 kg/m(2); median eGFR, 36.0 ml/min). Using the same prediction model and cutoff value, the AUROC was 0.842. NAFLD prevalence in CKD patients was comparable to that in the general population, increasing over time. Conclusions Our model using BMI, renal function, triglyceride-glucose index, serum alanine aminotransferase, and hemoglobin accurately predicted the presence of NAFLD in CKD patients.
DOI
10.1186/s12882-020-01718-8
Appears in Collections:
의과대학 > 의학과 > Journal papers
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