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Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application
- Title
- Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application
- Authors
- Jung, Euiyoung; Kim, Sung-Won; Cho, Ahyoung; Kim, Yu-Jin; Jeong, Gun-Jae; Kim, Jinheung; Bhang, Suk Ho; Yu, Taekyung
- Ewha Authors
- 김진흥
- SCOPUS Author ID
- 김진흥
- Issue Date
- 2019
- Journal Title
- MATERIALS
- ISSN
- 1996-1944
- Citation
- MATERIALS vol. 12, no. 23
- Keywords
- iron oxide; magnetite; nanoparticles; reverse micelle; sub-3 nm
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We report a synthetic method for small and uniform Fe3O4 (magnetite) nanoparticles under mild conditions. Spherical sub-3 nm-sized magnetite nanoparticles were prepared via reverse micelles composed of oleylamine, F127, xylene, and water for the reaction of iron(III) stearate with hydrazine at a reaction temperature of 90 degrees C in air atmosphere. These synthesized magnetite nanoparticles exhibited good size uniformity. By controlling experimental conditions, we could easily control both size and size uniformity of these magnetite nanoparticles. We further investigated whether Fe3O4 could be used in biomedical applications. Cytotoxicity of Fe3O4 was evaluated with human adipose-derived stem cells (hADSCs). Our results showed that the number of hADSCs did not significantly decrease when these cells were treated with Fe3O4 nanoparticles at a concentration of up to 9 mu g/mL. Apoptotic activity and cell proliferation of hADSCs treated with Fe3O4 nanoparticles were similar to those of hADSCs without any treatment. This novel method could be used for synthesizing uniform and biocompatible Fe3O4 nanoparticles with further biomedical applications.
- DOI
- 10.3390/ma12233850
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
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Synthesis of Sub 3 nm-Sized Uniform Magnetite.pdf(3.9 MB)
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