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A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles

Title
A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles
Authors
Song Y.Lee S.Dutta P.Ryu J.-S.
Ewha Authors
류재상
SCOPUS Author ID
류재상scopus
Issue Date
2020
Journal Title
Synthesis (Germany)
ISSN
0039-7881JCR Link
Citation
Synthesis (Germany) vol. 52, no. 5, pp. 744 - 754
Keywords
1,2,3-triazolesclick reactionscopper catalystmulticomponent reactionsone-pot reactions
Publisher
Georg Thieme Verlag
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH 2 is developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further converted into 1,2,3-triazole-fused tricyclic scaffolds. This method features an efficient one-pot cascade route using commercial alkynes and affords the corresponding 5-allyl-1,2,3-triazoles with high yields and good selectivity under mild reaction conditions. © 2020 Georg Thieme Verlag. All rights reserved.
DOI
10.1055/s-0039-1691506
Appears in Collections:
약학대학 > 약학과 > Journal papers
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