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Treatment Satisfaction with Flexible-dose Fesoterodine in Patients with Overactive Bladder who were Dissatisfied with Previous Anticholinergic Therapy: A Multicenter Single-Arm Clinical Study
- Title
- Treatment Satisfaction with Flexible-dose Fesoterodine in Patients with Overactive Bladder who were Dissatisfied with Previous Anticholinergic Therapy: A Multicenter Single-Arm Clinical Study
- Authors
- Choi, Jin Bong; Cho, Kang Jun; Park, Won Hee; Lee, Dong Hwan; Kim, Young-Ho; Cho, In Rae; Yoon, Hana; Kim, Young Sik; Kim, Joon Chul
- Ewha Authors
- 윤하나
- SCOPUS Author ID
- 윤하나
- Issue Date
- 2020
- Journal Title
- UROLOGY JOURNAL
- ISSN
- 1735-1308
1735-546X
- Citation
- UROLOGY JOURNAL vol. 17, no. 1, pp. 97 - 101
- Keywords
- fesoterodine; overactive bladder; patient satisfaction
- Publisher
- UROL &
NEPHROL RES CTR-UNRC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: We investigated treatment satisfaction with flexible-dose fesoterodine in patients with overactive bladder (OAB) who were dissatisfied with previous anticholinergic therapy. Materials and Methods: The subjects were prescribed fesoterodine 4 mg for 4 weeks and fesoterodine 4 mg or 8 mg for another 8 weeks. The primary end point of this study was patients' satisfaction after 12 weeks of fesoterodine treatment on a five-point Likert scale. Secondary end points included a change in the number of daytime micturition, urgency incontinence episodes, urgency episodes, and nocturnal micturition in a -24hour period from baseline to final assessment. Results: Overall, 84 patients were assigned to the treatment group in this study and 63 patients completed the -12week treatment course. A final fesoterodine dose of 4 mg and 8 mg was used by %71.4) 45) and %28.6) 18) patients, respectively. The satisfaction and dissatisfaction rates at 12 weeks were %69.9 and %14.2, respectively. Mean changes in the daytime micturitions (4.72 +/- 9.73 vs. 2.86 +/- 7.76), urgency episodes (5.68 +/- 7.73 vs. +/- 3.71 4.09), and nocturnal micturitions (1.36 +/- 2.13 vs. 1.12 +/- 1.68) in 24 hours improved significantly with flexible-dose fesoterodine treatment (P < .05). Most adverse events were mild and none were severe. Conclusion: The flexible dose fesoterodine represents an alternative treatment modality in patients with OAB who are dissatisfied with previous anticholinergic therapy in Korea.
- DOI
- 10.22037/uj.v0i0.4650
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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