View : 256 Download: 0

Diagnostic performance of a minimized protocol of non-contrast MRI for hepatocellular carcinoma surveillance

Title
Diagnostic performance of a minimized protocol of non-contrast MRI for hepatocellular carcinoma surveillance
Authors
Kim, Jin SilLee, Jeong KyongBaek, Seung YonYun, Hye In
Ewha Authors
백승연이정경김진실
SCOPUS Author ID
백승연scopus; 이정경scopus; 김진실scopus
Issue Date
2020
Journal Title
ABDOMINAL RADIOLOGY
ISSN
2366-004XJCR Link

2366-0058JCR Link
Citation
ABDOMINAL RADIOLOGY vol. 45, no. 1, pp. 211 - 219
Keywords
Mass screeningMagnetic resonance imagingPopulation surveillanceLiverCirrhosis
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose To evaluate the per-patient diagnostic performance of a minimized non-contrast MRI protocol for hepatocellular carcinoma (HCC) surveillance in cirrhotic liver, as well as factors affecting diagnostic sensitivity. Methods A total of 226 patients who underwent MRI for HCC surveillance over an 8 year period were included in this retrospective study. Set1 consisted of diffusion-weighted imaging and respiratory-triggered, fast-spin echo T2-weighted imaging with fat suppression. Set2 included T1-weighted in/opposed-phase images added to the images from Set1. Image sets were scored as positive or negative for HCC according to predetermined criteria by two readers independently. The diagnostic performance of the two sets in conjunction with alpha-fetoprotein (AFP) was assessed and compared using the McNemar test. Logistic regression was used to determine factors that affected sensitivity. Results The sensitivity, specificity, and accuracy of Set1 of readers 1 and 2 were 84.4%/87.3%, 86.8%/86.8%, and 85.0%/87.2%, respectively; and those for Set2 were 87.3%/89.6%, 81.1%/79.2%, and 85.8/87.2%, respectively. The sensitivities of the sets were not significantly different (p = 0.063). Sensitivities of both sets in conjunction with AFP were higher than those of MRI alone without statistical significance (87.3%/89.6%, p = 0.063/> 0.99; 89.6%/89.6%, p = 0.125/> 0.99). In very early-stage HCC, the sensitivities of Sets1 and 2 were 73.1%/76.9% and 76.9%/82.7%, respectively. Perihepatic ascites and size less than 2 cm were associated with sensitivity (p < 0.05). Conclusions A minimized non-contrast MRI protocol consisting of Fat-sat T2WI and DWI is highly sensitive and may be a viable method for HCC surveillance of the cirrhotic liver. The inclusion of T1-weighted in/opposed-phase and AFP may increase this sensitivity.
Show the fulltext
DOI
10.1007/s00261-019-02277-9
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE