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A 3D-printed polycaprolactone/β-tricalcium phosphate mandibular prosthesis: A pilot animal study
- Title
- A 3D-printed polycaprolactone/β-tricalcium phosphate mandibular prosthesis: A pilot animal study
- Authors
- Park J.H.; Jung S.Y.; Lee C.-K.; Ban M.J.; Lee S.J.; Kim H.Y.; Oh H.J.; Kim B.K.; Park H.S.; Jang S.-H.; Kim H.S.
- Ewha Authors
- 김한수; 정수연
- SCOPUS Author ID
- 김한수; 정수연
- Issue Date
- 2020
- Journal Title
- Laryngoscope
- ISSN
- 0023-852X
- Citation
- Laryngoscope vol. 130, no. 2, pp. 358 - 366
- Keywords
- 3D printing; Graft material; Osteogenesis; Stem cell
- Publisher
- John Wiley and Sons Inc.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: In this study, we assessed the effectiveness of a tonsil-derived mesenchymal stem cell (TMSC)-transplanted polycaprolactone/beta-tricalcium phosphate prosthesis (specifically designed for easier fixing and grafting with a single scaffold) on rabbit mandible osteogenesis. Methods: The mandibles of 18 rabbits were exposed, and 10 × 8-mm bone defects were made. Two rabbits did not receive implants; four were reconstructed with the scaffold control (SC) (SC group); four were reconstructed with scaffolds soaked in peripheral blood (PB) (PB group); four were reconstructed with TMSC-transplanted scaffolds (TMSC group); and four were reconstructed with differentiated osteocyte-transplanted scaffolds (DOC) (DOC group). Each rabbit was sacrificed 12 weeks after surgery, and the area of new bone formation was investigated by mechanical testing, histology, and micro-computed tomography. Results: More extended and denser new bone masses were observed in the TMSC and DOC groups, although fibrosis and vascular formation levels were similar in all groups, suggesting that the dual-structured scaffold alone provides a good environment for bone attachment and regeneration. The bone volumes of representative scaffolds from the SC, PB, TMSC, and DOC groups were 43.12, 48.35, 53.10, and 57.44% of the total volumes, respectively. Conclusion: The design of the scaffold resulted in effective osteogenesis, and TMSCs showed osteogenic potency, indicating that their combination could enable effective bone regeneration. Level of Evidence: NA Laryngoscope, 130:358–366, 2020. © 2019 The American Laryngological, Rhinological and Otological Society, Inc.
- DOI
- 10.1002/lary.27908
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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